Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Simultaneous Determination of Total and Unbound Amphotericin B by LC–MS/MS: Application to Protein Binding Analysis

ABSTRACT Amphotericin B (AmB), a first‐line antifungal agent, is highly protein‐bound, and its efficacy and toxicity are primarily determined by the unbound fraction. However, current therapeutic drug monitoring mainly relies on total plasma concentrations, and clinical data on u...

Latent profile analysis of postpartum depression symptoms and its associations with weight stigma and eating behaviors among postpartum women in China

Abstract Background Postpartum depression (PPD) represents a significant maternal health challenge with diverse symptom manifestations. Traditional analytical approaches that treat postpartum women as a homogeneous group may obscure distinct symptom patterns, limiting the develop...

Biomarker implications of gene editing in hematologic diseases: latest updates from ASH 2025

The 2025 American Society of Hematology (ASH) Annual Meeting highlighted rapid advances in gene editing for hematologic diseases, with increasing emphasis on precision editing and early exploration of in vivo delivery strategies. Beyond technological development, several measurab...

Effects of vegetarian or vegan diets on cardiovascular metabolic health in patients with cardiovascular disease: a systematic review and meta-analysis

Vegetarian or vegan diets have been associated with favorable cardiovascular outcomes in the general population; however, their effects on cardiometabolic risk factors in patients with established cardiovascular disease (CVD) remain unclear. This systematic review and meta-analys...

Familial tailgut cysts in two sisters presenting with sacral dimple sign: a case report

Tailgut cysts are rare congenital cystic lesions arising from remnants of the embryological postanal primitive gut. Familial clustering of tailgut cysts has been rarely reported, and the association with sacral dimple sign as an early diagnostic indicator remains underexplored. W...

Association between inflammatory bowel disease and ankylosing spondylitis: Mendelian randomization of a different database and meta-analysis

Inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) are common autoimmune disorders that have a serious impact on the physical and mental health of patients. Some patients with AS also suffer from IBD, and some studies have shown that there is a link between the 2. H...