Affiliated Hospital of North Sichuan Medical College

Research trends and hotspots in colorectal cancer screening

Background: Colorectal cancer (CRC), is a highly prevalent malignant tumor worldwide, and early screening is key to improving its prognosis. Currently, CRC screening research is growing exponentially, but its core research hotspots, evolutionary trends, and interdisciplinary feat...

Integrated network toxicology, transcriptomic, and Mendelian randomization analyses explore potential molecular links between acrylamide exposure and clear cell renal cell carcinoma

Acrylamide is a potential carcinogen widely encountered in occupational settings and heat-processed foods. However, the potential molecular relationships between acrylamide-associated targets and clear cell renal cell carcinoma remain poorly characterized. The toxicological chara...

Organelle contact sites as intracellular communication hubs linking metabolic stress to inflammatory disease

Abstract Membrane contact sites (MCSs) are specialized, non-fusogenic interfaces that allow organelles to exchange ions, lipids, metabolites and stress signals. These contacts support adaptation to nutrient, proteotoxic and inflammatory stress. However, persistent or misregulated...

A randomized controlled trial of internet-based cognitive behavioral therapy for sleep disturbances in ICU survivors

Objective To investigate the efficacy of Internet-based Cognitive Behavioral Therapy (ICBT) for sleep disturbances in patients discharged from the Intensive Care Unit (ICU). Methods A prospective, randomized controlled study was conducted, enrolling 120 patients with sleep distur...

Subtonsillar Approach to a Polylobulated Posterior Inferior Cerebellar Artery Aneurysm: A Case Illustration.

BACKGROUND AND IMPORTANCE: Dysplastic and polylobulated aneurysms of the posterior inferior cerebellar artery (PICA) present significant technical challenges because of their irregular geometry and proximity to the lower cranial nerves and brainstem perforators. When endovascular...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Nanoscale tire wear particles disrupt the blood–testis barrier and impair spermatogenesis through ROS–driven ferritinophagy and ferroptosis

Tire wear particles (TWPs) are a major source of micro- and nanoplastics. However, reports on nanoscale tire wear particles, especially regarding their potential hazards to the male reproductive system, remain scarce. Here, we examined whether nanoscale tire wear particles impair...

Integrative identification and preliminary validation of senescence-associated secretory phenotype-related candidate biomarkers in type 2 diabetes

Senescence-associated secretory phenotype (SASP)-related inflammatory programs have been implicated in type 2 diabetes mellitus (T2DM), yet blood-based candidates have not been systematically screened and validated across independent cohorts. We adopted standardized senescence si...

Precision localization of the anus using a smart defecation assistance system based on the YOLOv11n model

BackgroundExisting defecation-assistance devices generally lack automated anal localization and image-based screening for conditions that may preclude probe operation.ObjectiveTo develop and evaluate an image-based method for anal localization and abnormal-region detection in an...

Effects of high-frequency rTMS targeting the primary motor cortex on pain, function, and brain network connectivity in patients with chronic nonspecific low back pain: an exploratory fNIRS analysis of a randomized sham-controlled trial

This study evaluated the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on pain and functional outcomes in patients with chronic nonspecific low back pain (NSLBP) and explored intervention-related changes in resting-state brain functional connectivi...

EPHX2 Loss Promotes CRC Migration via EET ‐Dependent Chemokine Elevation and Mitochondrial Defect

ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and carcinogenesis. However, the role and mechanism of EPHX2 in colorectal cancer (CRC) migrati...

Multidimensional analysis of pulmonary blastoma: clinical, bibliometric and bioinformatic insights

Abstract Objective Pulmonary blastoma (PB) is a rare primary lung tumor, accounting for less than 0.5% of all lung cancers. Its epidemiological and clinical characteristics remain unclear, and the molecular pathogenesis had not been fully elucidated, which poses challenges to sta...

SGLT2 inhibitors for heart failure outcomes across baseline glycemic status: a systematic review and stratified meta-analysis of independent parent trial populations

Sodium-glucose cotransporter 2 (SGLT2) inhibitors improve heart failure outcomes, but whether relative effects are consistent across normoglycemia, prediabetes, and diabetes/type 2 diabetes remains uncertain. Linked publications from the same randomized populations may also be do...

Three latent subtypes of suicide risk and network characteristics of scale item associations among adolescents with major depressive disorder: a cross-sectional study

This study aimed to identify latent suicide risk subtypes among first-episode, treatment-naive adolescents with major depressive disorder (MDD), and to explore the item-level association patterns across subtypes, so as to provide evidence for optimizing stratified suicide risk sc...

Arachidonic acid metabolism-based stratification reveals immune microenvironment heterogeneity and defines a prognostic signature in triple-negative breast cancer

Arachidonic acid (AA) metabolic reprogramming has emerged as an important driver of tumor progression and immune escape. However, how AA metabolism–related genes (AAMRGs) contribute to immune microenvironment heterogeneity and clinical outcomes in triple-negative breast cancer (T...

Evaluation of the safety and efficacy of 225Ac-PSMA-CY313 in metastatic castration-resistant prostate cancer: preliminary results

Abstract Objective Metastatic castration-resistant prostate cancer (mCRPC) remains associated with poor long-term outcomes, and survival under current treatment is modest. Prostate-specific membrane antigen (PSMA)-targeted alpha therapy using 225 Ac exhibits superior cytotoxicity...

Nasopharyngeal Carcinoma With Multiple Metastases Detected by Al 18 F-NOTA-FAPI-04 PET/CT

Nasopharyngeal carcinoma (NPC) is a prevalent epithelial malignancy. NPC tends to infiltrate locally early and typically involves regional nodes. Patients with terminal disease often develop distant metastases. We report a case of NPC with multiple metastases on 18 F-FAPI-04 PET/...

MRI-based radiomic models of subchondral bone for predicting the occurrence of knee osteoarthritis

To extract the MRI-based radiomic features of subchondral bone, and establish multi-regional radiomic models and delta-radiomic models for predicting the 2-year risk of knee osteoarthritis (KOA). The data used in this study were obtained from the osteoarthritis initiative (OAI)....

Factors associated with inpatient medical record data quality in hospital settings: a systematic review

Inpatient medical record data are an important source of information for clinical care, hospital management, clinical coding, and reimbursement. Poor-quality record data may lead to incomplete documentation, coding errors, inaccurate performance assessment, and distorted reimburs...

Integrative network toxicology and transcriptomic analysis identifies candidate molecular links between drinking-water disinfection by-products and prostate cancer

Disinfection by-products (DBPs) are ubiquitous contaminants generated during drinking-water disinfection and have been associated with adverse health outcomes. Although epidemiological and toxicological studies have linked long-term DBP exposure to urinary tract malignancies, the...