Affiliated Hospital of Guizhou Medical University

Predicting left-ventricular recovery and characterizing Cardiorenal risk after Transcatheter aortic valve replacement: A routine-data phenotyping and prediction-model study

Background Ejection fraction (LVEF) underpins risk stratification before transcatheter aortic valve replacement (TAVR), yet it does not indicate whether an impaired ventricle will recover once the stenosis is relieved, or what drives death in high-risk patients. We asked whether...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

In Vitro Litholytic Effects of Three Chinese Herbal Extracts on Mixed-Type Urinary Calculi.

litholytic effects on this mixed-type calculus subtype，suggesting their potential as therapeutic agents for clinical management of urolithiasis.

Exploring the treatment of liver cancer with Gehua Hugan Gao based on bioinformatics, network pharmacology, and molecular docking

Gehua Hugan Gao (GHHGG) is a traditional Chinese medicine paste that is chiefly used to treat liver cancer. However, the potential impact of GHHGG on liver cancer remains unclear. We explored how GHHGG treats liver cancer using bioinformatics, network pharmacology, and molecular...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Cantharidin Causes Hepatotoxicity by Disrupting GSH‐Mediated Redox Homeostasis

ABSTRACT Cantharidin (CTD) possesses potent anticancer activity, whereas its prominent hepatotoxicity severely limits its clinical application. Because the detailed molecular mechanisms responsible for CTD‐triggered hepatotoxicity have not been fully elucidated, additional invest...

Multicenter Privacy‐Preserving Federated Models for Predicting Postoperative Delirium and Acute Kidney Injury in Older Patients

ABSTRACT Postoperative delirium (POD) and acute kidney injury (AKI) are serious complications in older patients undergoing surgery, yet predictive model development is often constrained by single‐center data limitations and privacy concerns that preclude centralized data sharing....

The relationship between UHR and heart failure: insights from two large database studies

Heart failure (HF) is a major cardiovascular disease that causes high incidence and mortality rates worldwide. The uric acid to high-density lipoprotein ratio (UHR), as an emerging inflammatory and metabolic composite indicator, has recently been considered to be associated with...

NIR-activated NO-propelled nanomotors for deep tumor penetration and DNA-repair sensitized photothermal therapy of prostate cancer

Photothermal therapy (PTT) for solid prostate cancer (PCa) is often limited by poor intratumoral penetration and rapid DNA repair. Herein, we engineered a PSMA-targeted gas nanomotor that couple deep tumor penetration with DNA repair sensitization for enhanced photothermal/NO the...

Transcriptomic characteristics of plasma from Chinese ethnic minority patients with major depressive disorder

Ethnic and regional disparities have been observed in the diagnosis and treatment of psychiatric disorders. Our previous research revealed metabolic heterogeneity in plasma samples from ethnic minority patients with schizophrenia in Qiandongnan, China. In this study, individuals...

Case report and literature review of synchronous follicular and papillary thyroid carcinoma with metastasis to femur

Thyroid carcinoma is common, but the synchronous occurrence of bilateral tumors with discordant histology—specifically follicular thyroid carcinoma (FTC) and papillary thyroid carcinoma (PTC)—is extremely rare. It is even more uncommon for such cases to present initially with dis...

Anlotinib combined with almonertinib reverses almonertinib resistance in lung adenocarcinoma by inhibiting the c-MET/PI3K/AKT pathway

Almonertinib resistance poses a major challenge in treating lung adenocarcinoma (LUAD) with epidermal growth factor receptor (EGFR) mutations. Research indicates that the c-MET/PI3K/AKT signaling pathway and epithelial-mesenchymal transition (EMT) are closely associated with resi...

Adelmidrol: A novel osteogenic mineralization regulator for bone defect repair via activating the Notch pathway with drug-loaded hydrogel

Bone defect, irreversible bone loss impairing physiological functions, raises complication risks, lowers life quality and burdens healthcare, demanding effective novel repair strategies. This study aimed to screen candidate drugs promoting osteoblast (OB) osteogenic mineralizatio...