Affiliated Hospital of Guizhou Medical University

Multicenter Privacy‐Preserving Federated Models for Predicting Postoperative Delirium and Acute Kidney Injury in Older Patients

ABSTRACT Postoperative delirium (POD) and acute kidney injury (AKI) are serious complications in older patients undergoing surgery, yet predictive model development is often constrained by single‐center data limitations and privacy concerns that preclude centralized data sharing....

The relationship between UHR and heart failure: insights from two large database studies

Heart failure (HF) is a major cardiovascular disease that causes high incidence and mortality rates worldwide. The uric acid to high-density lipoprotein ratio (UHR), as an emerging inflammatory and metabolic composite indicator, has recently been considered to be associated with...

NIR-activated NO-propelled nanomotors for deep tumor penetration and DNA-repair sensitized photothermal therapy of prostate cancer

Photothermal therapy (PTT) for solid prostate cancer (PCa) is often limited by poor intratumoral penetration and rapid DNA repair. Herein, we engineered a PSMA-targeted gas nanomotor that couple deep tumor penetration with DNA repair sensitization for enhanced photothermal/NO the...

Transcriptomic characteristics of plasma from Chinese ethnic minority patients with major depressive disorder

Ethnic and regional disparities have been observed in the diagnosis and treatment of psychiatric disorders. Our previous research revealed metabolic heterogeneity in plasma samples from ethnic minority patients with schizophrenia in Qiandongnan, China. In this study, individuals...

Case report and literature review of synchronous follicular and papillary thyroid carcinoma with metastasis to femur

Thyroid carcinoma is common, but the synchronous occurrence of bilateral tumors with discordant histology—specifically follicular thyroid carcinoma (FTC) and papillary thyroid carcinoma (PTC)—is extremely rare. It is even more uncommon for such cases to present initially with dis...

Anlotinib combined with almonertinib reverses almonertinib resistance in lung adenocarcinoma by inhibiting the c-MET/PI3K/AKT pathway

Almonertinib resistance poses a major challenge in treating lung adenocarcinoma (LUAD) with epidermal growth factor receptor (EGFR) mutations. Research indicates that the c-MET/PI3K/AKT signaling pathway and epithelial-mesenchymal transition (EMT) are closely associated with resi...

Adelmidrol: A novel osteogenic mineralization regulator for bone defect repair via activating the Notch pathway with drug-loaded hydrogel

Bone defect, irreversible bone loss impairing physiological functions, raises complication risks, lowers life quality and burdens healthcare, demanding effective novel repair strategies. This study aimed to screen candidate drugs promoting osteoblast (OB) osteogenic mineralizatio...