Affiliated Hospital of Guizhou Medical University

Differences in perceived influences and educational support needs of generative AI among medical and nursing students across educational levels: a descriptive qualitative study

Generative artificial intelligence (GAI) has been extensively integrated into nursing and medical education, significantly transforming the academic practices of students. Nonetheless, the varying impacts of GAI on core competency of student across educational stages remain ambig...

Implementation and perioperative safety of a standardized multidisciplinary care pathway for percutaneous endoscopic transforaminal discectomy in patients aged ≥ 85 years: a two-center retrospective study

Although the comparative effectiveness of multidisciplinary team (MDT)-supported percutaneous endoscopic transforaminal discectomy (PETD) has been reported in selected patients aged ≥ 85 years, less is known about the implementation and perioperative safety of a standardized MDT...

Noninvasive ultrashort wave neuromodulation enhances glymphatic clearance to alleviate traumatic brain edema and Alzheimer’s pathology

The glymphatic system clears cerebral waste, yet strategies to enhance its function remain elusive. Here, we show that 40.68 MHz ultrashort wave (USW) rapidly enhances glymphatic bulk flow in healthy mice within 10 minutes. USW potentiates both glymphatic influx and efflux, conco...

An expert routing-driven graph framework from tongue multi-task features to liver fibrosis prediction

Liver fibrosis is a global health concern where early detection is crucial for timely intervention. Traditional Chinese Medicine tongue diagnosis offers a promising non-invasive assessment, but suffers from inter-observer variability and subjective interpretation. Current artific...

Serial Cross‐Sectional Mapping of Bone Marrow Microenvironment Remodelling During Fracture Repair Using Multiparametric MRI and Histopathology

ABSTRACT Restoring bone marrow microenvironment (BMM) homeostasis is critical for fracture healing, yet non‐invasively tracking physiological events like apoptosis, angiogenesis and matrix remodelling remains challenging. This study evaluated multiparametric 7.0T MRI (T2 mapping...

Independent prognostic value of the blood urea nitrogen-to-albumin ratio beyond the creatinine-to-albumin ratio among eICU patients with recorded sepsis and acute respiratory failure: a retrospective cohort study

Patients recorded as having both sepsis and acute respiratory failure (ARF) constitute a high-risk critically ill population, although historical database-based sepsis classifications may not correspond directly to contemporary Sepsis-3 criteria. The blood urea nitrogen-to-albumi...

Genomic characteristics and evolutionary analysis of Bordetella pertussis in Guizhou Province, China

Abstract Background Pertussis is an acute infectious respiratory disease caused by Bordetella pertussis (Bp). Despite high vaccination coverage, the genome of B. pertussis is prone to variations. These variations can lead to vaccine immune escape, recurrence of outbreaks, and inc...

Exploring the Mechanism of Postpartum Cognitive Dysfunction in a Preeclampsia Rat Model via Multimodal Imaging

Preeclampsia (PE) affects 3%-5% of pregnancies worldwide and is a leading cause of maternal/perinatal mortality, yet its etiology remains unknown. We established a PE rat model using L-NAME to investigate postpartum cognitive dysfunction and its mechanisms, evaluated brain micros...

SARS-CoV-2 NSP14 suppresses RIG-I-mediated interferon production by dampening the interaction between DHX15 and RIG-I

Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) imposes serious public health and economic burdens worldwide. SARS-CoV-2 has evolved a formidable arsenal of evasion strategies to outmaneuver innate immune responses. However, the role of nonstructural p...

A Selective ERα Photodegrader for Precise and Efficient Breast Cancer Treatment

Abstract Breast cancer is the most prevalent malignancy in women, with over 70% of cases being estrogen receptor α (ERα)-positive. Photodynamic therapy (PDT) is spatially precise yet limited by tumor-selective photosensitizers. Herein, we report the first co-crystal structure of...

Diagnostic value of LRG-1 in combination with inflammatory factors for the severity and poor prognosis of acute cholecystitis

Accurate stratification of acute cholecystitis (AC) severity and prognosis remains challenging. Leucine-richα-2-glycoprotein-1 (LRG-1) is an inflammatory biomarker, but its role in assessing AC severity has not been studied. This study aimed to investigate the diagnostic and prog...

Cost-Utility Analysis of Comprehensive Integrated Management for Psoriasis and Periodontitis: A Markov Cohort Study

Objectives Psoriasis and periodontitis co-occur in Chinese adults beyond chance expectation, sharing proinflammatory pathways. We modelled the long-term economic value of integrating periodontal care into psoriasis management in China. Methods A nine-state Markov cohort model (1-...

Generalized Cutaneous Hyperpigmentation and Lentigines due to KIT Variant

Activating KIT mutations are a rare cause of progressive hyperpigmentation and lentigines, with or without gastrointestinal stromal tumors (GISTs) , and effective treatments for the pigmentary phenotype remain limited. We report a family with generalized hyperpigmentation and len...

Bedside rapid lactate-creatinine-to-platelet ratio score and short-term mortality prognosis in patients with aspiration pneumonia complicated by sepsis: a multicenter cohort study

This study aimed to investigate the association between the rapid bedside Lactate-Creatinine-to-Platelet Ratio (LCPR) and short- to medium-term mortality prognosis in patients with aspiration pneumonia complicated by sepsis. This retrospective database-based observational study i...

ZIF-8-Based Smart-Responsive Nanocomposites for Cutaneous Wound Healing: A Review

Abstract Cutaneous wound healing is a complex process that requires precise management. In recent years, intelligent, responsive biomaterials have played a crucial role in guiding wound healing through these stages in a physiologically ordered manner. Zeolitic imidazolate framewo...

Modulation of CD73 by Betulinic acid antagonizes nucleotide metabolic dysregulation in silica nanoparticle-induced pulmonary fibrosis

Silica nanoparticles (SiNPs) exposure presents a growing public-health concern. The mechanisms driving SiNPs-induced pulmonary fibrosis and effective interventions remain unclear. This study investigated the contribution of CD73 to SiNPs-induced pulmonary fibrosis and evaluated t...

Beyond motor symptoms: associations between sleep disorders and multidomain functional decline in Parkinson’s disease

Sleep disorders are associated with functional outcomes in Parkinson’s disease (PD), yet their multidomain clinical correlates remain incompletely characterized. We analyzed 9195 participants from the National Alzheimer’s Coordinating Center database using inverse probability wei...

ALOX15-Inhibitory Peptides Derived from Coffee Bean Protein Hydrolysates Confer Neuroprotection against Lipid Peroxidation

Abstract Coffee beans are widely consumed worldwide and are known for their central nervous system-stimulating effects, mainly attributed to caffeine and other small molecules. However, the neuroprotective potential of coffee bean-derived peptides remains largely unexplored. In t...

VEGF ‐A Antisense Oligonucleotide Therapy Inhibits Corneal Neovascularisation and Enhances Graft Survival in Murine High‐Risk Corneal Transplantation

BACKGROUND: To investigate, for the first time, whether an unconjugated VEGF-A antisense oligonucleotide (ASO) can inhibit corneal neovascularisation and improve graft survival in a murine high-risk corneal transplantation model. METHODS: A suture-induced corneal neovascularisati...

LRCH4 drives tumor cell proliferation by regulating the GSK3B/MEK/ERK axis in colorectal cancer

Abstract Leucine-rich repeat-containing protein 4 (LRCH4), a member of the LRCH family, has emerged as a potential prognostic biomarker in several cancers, including colorectal cancer (CRC). While other proteins in this family have been implicated in tumorigenesis, the specific r...