Acıbadem University

Sodium perborate tetrahydrate modulates neuroinflammation and reduces Leishmania infantum infection in astrocytes

Abstract Leishmaniasis is a neglected tropical disease caused by protozoan parasites of genus Leishmania . Although the parasites are classically considered macrophage-resident pathogens, accumulating evidence suggests that Leishmania can cross the blood–brain barrier and induce...

Multimodal ophthalmic findings in patients with mucopolysaccharidosis: A prospective observational study

Purpose To characterize ocular involvement in pediatric patients with mucopolysaccharidosis (MPS) using multimodal assessment, with emphasis on corneal densitometry and visual electrophysiology. Methods This prospective observational study included 22 patients with molecularly co...

Bracing in adult scoliosis: a scoping review of clinical outcomes

Bracing is commonly used as a conservative treatment for scoliosis, but its effects in adults with scoliosis remain unclear. To map and synthesize the existing evidence on the effects of bracing in adults with scoliosis, focusing on radiological outcomes, pain, physical function,...

Quality Evaluation of Commercial Products Marketed as Thymus vulgaris L. Essential Oil According to European Pharmacopoeia 10.0 Criteria

Essential oils are mixtures of complex secondary metabolites with variable chemical compositions that determine their therapeutic effects. Thyme oil, obtained from the fresh or dried leaves and flowers of Thymus spp. through steam distillation, is widely used in food, pharmacy, a...

The effect of pilates on sleep quality in pregnancy: a systematic review and meta-analysis

Sleep disturbances are common during pregnancy and are associated with adverse maternal and fetal outcomes. Non-pharmacological interventions, particularly exercise, are increasingly recommended to improve sleep quality. This study aimed to evaluate the effect of Pilates exercise...

New guidelines for the prevention of periprosthetic joint infection

Periprosthetic joint infection (PJI) remains one of the most serious complications of arthroplasty. Since the publication of major guidelines, several aspects of the prevention of PJI have been refined, although high-quality evidence remains limited in many areas. The aim of this...

Cycling-related injuries demonstrate the highest hospitalization proportion, whereas exercise-related activities account for the largest injury burden: a 12-year national epidemiological analysis

Sports- and recreation-related injuries represent a substantial public health burden, yet comprehensive national analyses comparing high-volume activities across all age groups remain limited. The purpose of this study was to describe temporal patterns, demographic distributions,...

Evaluation of the pSOFA Score in a Pediatric Intensive Care Unit and Its Discriminative Performance Compared with PRISM 4 and PIM 3

Objectives: We aimed to evaluate the performance of the age-adapted Pediatric Sequential Organ Failure Assessment (pSOFA) score, as a predictor of mortality in patients admitted to pediatric intensive care units (PICUs), and to compare it with the Pediatric Risk of Mortality 4 (P...

Alternate-Day Versus Consecutive-Day Anti-T Lymphocyte Globulin Induction in First Living-Donor Kidney Transplant Recipients at Low Immunological Risk: A Retrospective Cohort Study

Background/Objectives: Anti-T lymphocyte globulin (ATLG) is widely used as induction therapy in kidney transplantation; however, the clinical impact of the interval between individual ATLG doses remains poorly defined. We compared alternate-day and consecutive-day ATLG administra...

The Blastocystis-colorectal cancer hypothesis: correlation is not causation

Introduction Emotional empathy is a key component of medical professionalism, enhancing doctor–patient communication, trust, treatment adherence, and clinical outcomes. However, research suggests that emotional empathy tends to decline during medical education, with potential neg...

Delivering the EU Safe Hearts Plan: the essential role of laboratory medicine in cardiovascular health

Abstract The European Union Safe Hearts Plan provides an opportunity to strengthen cardiovascular prevention, early detection, treatment, and monitoring across Europe. This EFLM position paper argues that laboratory medicine must be recognized as a central component of its implem...

From Metabolism to Molecular Phenotype: Carbonic Anhydrase IX–Targeted [ 68 Ga]Ga-DPI-4452 PET/CT in Renal Cell Carcinoma: A Prospective Multicenter Comparison with [ 18 F]FDG PET/CT

The objective of this study was to prospectively compare the diagnostic performance, lesion detection capability, and clinical staging impact of [68Ga]Ga-DPI-4452 PET/CT with that of [18F]FDG PET/CT in renal cell carcinoma (RCC) using a multicenter design. Methods: Sixty-eight pa...

Clinical Outcomes of Robotic and Laparoscopic Ileal Pouch–Anal Anastomosis in Ulcerative Colitis: A Retrospective Cohort from Two Tertiary Referral Centers

Background: Robotic platforms may facilitate the technically demanding pelvic and multiquadrant components of ileal pouch-anal anastomosis (IPAA), but comparative evidence remains limited. Methods: We retrospectively compared 90-day outcomes after robotic ( n = 36) and laparoscop...

Nontraumatic Osteonecrosis of the Femoral Head: An Update.

➢ Nontraumatic osteonecrosis of the femoral head should be suspected in patients who are <50 years of age who have persistent hip pain despite normal radiographs. ➢ Bilateral involvement is common; magnetic resonance imaging (MRI) of the contralateral hip is recommended. ➢ MRI is...

Artificial Intelligence in Endometriosis Management: A Guideline-Concordance Study

Objective: This study aimed to evaluate how closely artificial intelligence (AI)- generated clinical recommendations correspond with established international guidelines for endometriosis management, using structured clinical scenarios.Methods: This study assessed the consistency...

Safety and Feasibility of Axillary Artery Cannulation In Robotic Assisted Minimally Invasive Coronary Revascularization

Purpose: Axillary artery cannulation is associated with safer results and fewer complications compared to femoral artery cannulation in minimally invasive cardiac surgery. Coronary artery bypass surgery patients present with a high atherosclerotic burden, and thus may also benefi...

Clinical Characteristics and Thyroid Findings in Children with Isolated Premature Adrenarche

Objectives: Premature adrenarche (PA) is associated with accelerated adrenal maturation, but data regarding thyroid characteristics in children with isolated PA are limited. We aimed to describe the clinical features of children with idiopathic PA and investigate the relationship...

Pilot evaluation of pathogen isolation using targeted amplicon next-generation sequencing on sonication fluid for the diagnosis of periprosthetic joint infections

Abstract Background Periprosthetic joint infection (PJI) remains difficult to diagnose due to the limited sensitivity of conventional culture, which frequently yields false-negative results. Targeted amplicon next-generation sequencing (tNGS) offers a method capable of identifyin...

Real-world outcomes of second-line therapy in advanced thymic carcinoma: a multicenter Turkish Oncology Group (TOG) study

Abstract Background Thymic carcinoma (TC) is a rare and aggressive malignancy with limited evidence guiding second-line treatment after prior systemic therapy. We evaluated real-world outcomes of second-line systemic therapy in a multicenter cohort. Methods Adults with unresectab...

ACUTE EFFECTS OF FOAM ROLLING AND PNF STRETCHING AS WARM-UP STRATEGIES ON MUSCLE FLEXIBILITY, STRENGTH, AND PRESSURE PAIN THRESHOLD IN AMATEUR ATHLETES

Objective: This study aimed to compare the acute effects of foam rolling (FR) and proprioceptive neuromuscular facilitation (PNF) stretching on hamstring flexibility, isometric knee flexion strength, vertical jump performance, and pressure pain threshold (PPT) in amateur athletes...