Aalborg University

Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC

Abstract Despite a decade in, immunotherapy (IO) treatment selection in non-small cell lung cancer (NSCLC) remains largely guided by subgroup analyses and imperfect programmed death ligand 1 (PD-L1) and clinical scores. To our knowledge, I 3 LUNG ( NCT05537922 ) is currently the...

Precision ID mtDNA Whole Genome Panel and sequencing of telogen hairs – perspectives for validation and implementation in casework

Abstract Shed hair is a commonly encountered type of forensic evidence. Shed telogen hairs generally contain insufficient or highly degraded nuclear DNA for STR profiling; however, mtDNA analysis of telogen hair and hair shafts remains possible. We validated whole mitochondrial g...

Trends in early-onset cancer incidence rates in the Nordic countries (2003–2022): a population-based study

Background Increasing incidence rates of early-onset cancer at ages 20–49 years have been reported in several countries, especially for colorectal, kidney and breast cancer. We examined recent incidence trends of early-onset cancer in Denmark, Finland, Iceland, Norway, Sweden, Gr...

Phenotypic manifestations and variant reclassification of germline PTEN variants: a nationwide Danish study

Background Classification of heterozygous germline PTEN variants in patients with, or suspected of having, PTEN hamartoma tumour syndrome (PHTS) remains challenging. Accurate classification is essential as these patients require lifelong cancer surveillance. Methods We identified...

Investigating social drones for recreational running through co-design

Introduction Human-drone interaction is an emerging field investigating ways to extend the conventionally passive role of drones with autonomous, socially interactive functionalities. Drones offer unique opportunities for applications, such as exercise support, due to their mobil...

Osseoperceptive EMG Feedback Improves Grasp Force Control in Myoelectric Prosthetic Hands

Restoring sensory feedback is essential for achieving accurate and natural control of myoelectric prosthetic hands, yet most clinical systems remain open loop. Osseoperception, the transmission of vibrotactile and auditory sensations through bone-conducted mechanical stimulation,...

Strained Partnership: Biocompatibility and Transcriptomic Responses of Hydrogenotrophic Methanogens to Methyl Diethanolamine in Bio-integrated Carbon Capture and Utilization

Abstract Biointegrated carbon capture and utilization (BICCU) represents a promising alternative to conventional carbon capture technologies, combining microbial methanogenesis with CO2 capture agents, such as methyl diethanolamine (MDEA), to produce renewable methane from dilute...

A data-selective strategy for online lithium-ion battery parameter estimation based on vehicle trip data

Accurate online battery parameter estimation methods are highly important in Electric Vehicle (EV) applications for ensuring battery pack performance and safety under dynamic conditions. To this end, it is necessary for the estimation method to provide low-bias and low-variance e...

Genome-wide association analysis of endometriosis in Indian women supports shared genetic susceptibility and suggestive population specific signals

Endometriosis is an estrogen-dependent, chronic gynaecological disorder affecting approximately 10% of women of reproductive age and is associated with pelvic pain, infertility, and reduced quality of life. Genetic studies indicate substantial heritability, yet genome-wide associ...

Risk of bone metastases on [18F]NaF PET/CT in 734 patients with newly diagnosed prostate cancer

Abstract Purpose International guidelines recommend assessment for bone metastases in patients with high-risk prostate cancer (PC) and those with unfavourable intermediate-risk disease. These recommendations are largely based on studies using planar bone scintigraphy. We aimed to...

Prevalence and Clinical Correlates of Autistic Traits Across Eating Disorder Diagnoses: A Retrospective Analysis of Clinical Service Data

Background: Autistic traits are overrepresented among individuals with anorexia nervosa (AN) and are associated with greater eating disorder (ED) psychopathology, psychological distress, and work and social functioning difficulties in this population. However, less is known about...

Routing and Downlink Resource Allocation for Multicast Traffic in LEO Satellite Constellations

ABSTRACT In this work, we optimize unicast and multicast traffic delivery over non‐terrestrial networks (NTNs) to users on the ground through direct satellite downlink (DL). We consider a gateway‐free mesh architecture with low Earth orbit (LEO) satellites interconnected via inte...

A Modified Delphi Study on the Ethics and Governance of Live Injecting at Aesthetic Conferences. Is There a Better and Safer Alternative?

BACKGROUND: Live clinical demonstrations at aesthetic medicine conferences is common, yet concerns regarding patient safety, commercial influence, and ethical governance. This study established a consensus-based governance framework for live injecting and compared expert and atte...

The green divide: renewable energy shaping community coherence

While renewable energy (RE) is crucial for the green transition, this contribution sheds light on how the process of proposing and implementing RE projects negatively impacts community coherence. The paper discusses the complexities of implementing RE projects in local communitie...

Orchestration Up Close: Sustainable Business Model Innovation Through the Experiences and Activity Patterns of Secondary Stakeholders

ABSTRACT While much research stresses the importance of stakeholder involvement and inter‐organizational collaboration in sustainable business model innovation, less is known about the dynamics and actor roles of these collaborative processes. This article investigates one partic...

Regional Variation in ADHD Treatment and Diagnosis Among Children and Adolescents in Denmark

ABSTRACT Geographic variation in ADHD treatment and diagnosis among children and adolescents is well documented, yet the system‐level factors driving such differences remain poorly understood. We examined nationwide patterns of ADHD medication use and diagnoses in Denmark in 2024...

Process measures developed for the routine monitoring of low-value care with electronic health data: A scoping review

Background Low-value care (LVC) are medical services where the potential harms or costs outweigh expected clinical benefits. Despite growing adherence to initiatives such as Choosing Wisely, approaches to routinely monitor and reduce LVC across healthcare systems remain limited....

Optimizing wollastonite treatment to enhance sustainability and reduce carbon emissions in cement-based materials

The sustainable use of natural minerals in construction materials is vital for minimizing the cement industry's environmental impact. Wollastonite, a calcium silicate mineral, offers significant potential as a supplementary cementitious material to reduce carbon emissions and enh...

Bivalent RSV Prefusion F Vaccine to Prevent Hospitalizations in Adults

BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of severe respiratory disease in adults, with the highest burden among older adults and individuals with chronic health conditions. The bivalent RSV prefusion F (RSVpreF) vaccine has been shown to prevent RSV-ass...

Selective Packaging of miR‐22 and miR‐29 Orthologues into Extracellular Vesicles of the Porcine Whipworm Trichuris Suis

ABSTRACT Helminths modulate host immunity, and in this respect, the porcine whipworm Trichuris suis has been explored clinically as an immunotherapy for inflammatory diseases. T. suis secretes a complex mixture of excretory/secretory products (ESP), including extracellular vesicl...