Zhenyan Xiao

Small-molecule cocktail 2SM promotes heart regeneration via inducing embryonic-like cardiomyocyte state

Adult mammalian cardiomyocytes exhibit limited regenerative capacity, which remains a major challenge for functional recovery after myocardial infarction (MI). Our previous study identified a cocktail of five small molecules (5SM) that promotes cardiomyocyte proliferation and hea...