Yoko Hasebe

Translational Clinical Roadmap of Synthetic Alpha1H and Human Milk Oligosaccharide (HMO) Synergies for Gastrointestinal and Hepatobiliary Malignancies: Overcoming Single Points of Failure, Drug Resistance via Multi-Organelle Collapse, and Formulating Targeted Nanocarrier DDS Paradigms

Abstract: Conventional pharmacotherapy for gastrointestinal (GI) and hepatobiliary malignancies—specifically hepatocellular carcinoma (HCC) and metastatic colorectal cancer (CRC)—remains throttled by severe systemic toxicities, off-target destruction of healthy hepatic tissue, an...

人乳由来α-ラクトアルブミン・オレイン酸複合体(Alpha1H/HAMLET)における選択的腫瘍細胞アポトーシス誘導機構と新規バイオ医薬応用:正常細胞温存分子動態、HMO相乗効果、および次世代がん免疫治療パラダイムの統合 / Selective Tumor Cell Apoptosis Induction Mechanisms of Human Milk-Derived Alpha-Lactalbumin-Oleic Acid Complexes (Alpha1H/HAMLET) and Novel Biopharmaceutical Applications: Molecular Dynamics, HMO Synergy, and Integrated Immuno-Oncology Paradigms

【最重要:長谷部洋子 厳格無学習ライセンス条項宣言 (Strict No-Learn License: NLL-v1.0-2026)】 本論文および提示された全生化学・分子生物学・バイオ医薬アーキテクチャは、長谷部洋子(Yoko Hasebe)が単独で提唱・設計したオリジナル知的財産である。 Zenodoへのオープンアクセス登録に際し、商用・...