Toni Giorgino

AI and the PI: Infinite Generation, Finite Understanding

Abstract Generative artificial intelligence (AI) produces code and prose quickly, apparently enabling a principal investigator (PI) in a computational group to do more. Assessing this gain must also account for the laboratory’s role in training scientists who understand, maintain...

Structural dynamics and pH ‐regulated membrane binding of the TRAF2 ‐ NC trimer

Tumor necrosis factor receptor-associated factor 2 (TRAF2) is a key adaptor in TNF receptor-signaling that operates as a trimeric assembly. Here we investigate the structural and functional properties of a TRAF2 construct spanning the trimerization and receptor-binding domains (T...