Stefan Ludwig Ameres

Separable roles for Microprocessor and its cofactors ERH and SAFB1/2 during microRNA cluster assistance

Results of the smallRNA analysis pipeline used in "Separable roles for Microprocessor and its cofactors ERH and SAFB1/2 during microRNA cluster assistance". 20251028_mirbase_results.tar.gz : GZIP archive of the analysis pipeline results. NOTE that full genome alignment BAMs from...

A pseudohelicase-centered complex couples assembly-dependent RNA cleavage to poly(UG)ylation

Robust RNA interference in Caenorhabditis elegans requires Argonaute targeted RNAs to be cleaved by RDE 8 and poly(UG)ylated by MUT 2, generating templates for RNA dependent RNA polymerases that synthesize secondary small RNAs. RDE 8 and MUT 2 are physically coupled within the cl...