Sijing Zhao

Transcriptomic convergence and the female protective effect in autism

ABSTRACT Autism spectrum disorder (ASD) is highly heritable, and mutations in hundreds of genes have been implicated as individually rare causes of ASD 1–3 . Understanding how disruptions to these functionally diverse genes lead to the core features of ASD remains a major challen...

Perinatal elimination of genetically aberrant human cortical neurons

Abstract Human neurons are postmitotic and long-lived, requiring precise genomic regulation. Normal neuronal function is highly dosage-sensitive, with copy number variants (CNVs) and heterozygous point mutations associated with a host of neurodevelopmental and neuropsychiatric co...