Peter A. van Veelen

DNA end-resection is stimulated by an interaction between BRCA1 exon 11 and TOPBP1

Abstract Approximately 60% of the tumour suppressor protein BRCA1 is encoded by a single exon. Many tumours carry mutations in this exon, often resulting in exon skipping and thus a protein of a severely reduced size. Although none of the well-described protein domains of BRCA1 a...

CRISPR activation screen uncovers MARCKSL1 as a gauge for extracellular vesicle secretion

Extracellular vesicles (EVs) are crucial mediators of intercellular communication that originate from diverse membrane reservoirs. In a genome-wide CRISPR activation screen, Zhong et al. identified MARCKSL1—a membrane adaptor upregulated across many tumor types—as a potentiator o...