Osuke Doijiri

A Recoverable Summer-Temperature Signature in Relative Wing Size of the Damselfly Lestes sponsa Out-of-population inverse prediction and spatial-block validation of an environmental morphological signal

Environmental effects on insect wing morphology are well established, and geographic variation in Lestes sponsa wing size and shape has already been described [1-9]. Here we ask a distinct inverse question: can summer temperature be recovered from wing morphology of a population...

A Recurrent Slc17a6-High Glutamatergic Microdomain in the Parabrachial Region Following Paclitaxel Exposure: GPR12-Associated Delayed Neuronal Remodeling Across Mouse Spatial and Human Time-Resolved Transcriptomics

BackgroundBuilding on this spatial observation, we asked whether a receptor-associated program could identify a molecular entry point into thepersistent state. GPR12, an orphan G protein-coupled receptor with constitutive Gs/cAMP activity and established neuronalexpression, emerg...

A Recurrent Slc17a6-High Glutamatergic Microdomain in the Parabrachial Region Following Paclitaxel Exposure: GPR12-Associated Delayed Neuronal Remodeling Across Mouse Spatial and Human Time-Resolved Transcriptomics

BackgroundBuilding on this spatial observation, we asked whether a receptor-associated program could identify a molecular entry point into thepersistent state. GPR12, an orphan G protein-coupled receptor with constitutive Gs/cAMP activity and established neuronalexpression, emerg...

A Recurrent Slc17a6-High Glutamatergic Microdomain in the Parabrachial Region Following Paclitaxel Exposure: A Whole-Brain Spatial Transcriptomic Reanalysis

BackgroundPaclitaxel is a widely used antineoplastic agent whose therapeutic utility is limited by persistentneurological adverse effects, including chemotherapy-induced peripheral neuropathy (CIPN). Mostmechanistic studies of paclitaxel neurotoxicity have focused on peripheral s...

A Candidate ALS-Associated Astrocytic Morphogeometric Microdomain:From a Continuous Vimentin-Positive Morphology Axis to Local Multicellular Spatial Organization

Amyotrophic lateral sclerosis (ALS) is accompanied by astrocytic reactivity, altered glial signaling and changes in astrocyte morphology, but it remains unclear whether disease-associated morphology is organized only at the level of individual cells or can form reproducible local...

Eelgrass Structural State Is Associated with Climate- and Terrain-Dependent Coastal Thermal Sensitivity A multi-scale open-data analysis of Zostera marina thermal microclimates, natural structural loss, bathymetry, predictive validation, and global scenario projection

Seagrass meadows are shaped by temperature, light, exposure, tidal exchange, and bathymetry, yet whether eelgrassstructural state is related to the transmission of regional thermal forcing into local meadow temperatures remainsunresolved. We introduce a thermal-sensitivity framew...

Eelgrass Structural State Is Associated with Climate- and Terrain-Dependent Coastal Thermal Sensitivity A multi-scale open-data analysis of Zostera marina thermal microclimates, natural structural loss, bathymetry, predictive validation, and global scenario projection

Seagrass meadows are shaped by temperature, light, exposure, tidal exchange, and bathymetry, yet whether eelgrassstructural state is related to the transmission of regional thermal forcing into local meadow temperatures remainsunresolved. We introduce a thermal-sensitivity framew...

A Reproducible ALS-Enriched Astrocytic Cross-State Transcriptional Axis Across Two Independent Human Spinal-Cord snRNA-seq Cohorts A DPP10/NRXN3/CD44/DCLK1/GLIS3-centered coordinated state bridging previously separable astrocytic transcriptional configurations

Astrocytes contribute to amyotrophic lateral sclerosis (ALS) through non-cell-autonomous and inflammatory mechanisms, yet disease-associated astrocytic heterogeneity remains difficult to summarize with discrete cluster labels alone. Here, we reanalyzed two independent public huma...

A Reproducible ALS-Enriched Astrocytic Cross-State Transcriptional Axis Across Two Independent Human Spinal-Cord snRNA-seq Cohorts A DPP10/NRXN3/CD44/DCLK1/GLIS3-centered coordinated state bridging previously separable astrocytic transcriptional configurations

Astrocytes contribute to amyotrophic lateral sclerosis (ALS) through non-cell-autonomous and inflammatory mechanisms, yet disease-associated astrocytic heterogeneity remains difficult to summarize with discrete cluster labels alone. Here, we reanalyzed two independent public huma...

The Molecular Information Boundary of Neuronal Electrical Waveforms

Neuronal electrophysiology and gene expression are coupled, but it remains unclear whether an electrical waveform contains a broadly decodable representation of the transcriptome or only selected molecular information. We analyzed paired public Patch-seq current-clamp recordings...

From Injury Canalization to Molecular Rescue: A Human-Derived Retinal Ganglion Cell State Space Predicts Optic Nerve Injury and Treatment Response

Background: Retinal ganglion cell (RGC) injury is typically analyzed by cell type, differential expression, or treatment-specificregeneration programs. A complementary question is whether injury and therapeutic response occupy a common molecularstate space that can be specified i...

Cross-Species Local Organization of Intrinsic Spatiotemporal Speed Scales in Retinal Ganglion Cell Functional Manifolds

We asked whether retinal ganglion cells (RGCs) possess a locally organized intrinsic spatiotemporal speed scalethat is reproducible across vertebrate species. For each RGC, a characteristic scale was defined as v* =sigma/tau, where sigma denotes a receptive-field spatial scale an...

Cross-Species Local Organization of Intrinsic Spatiotemporal Speed Scales in Retinal Ganglion Cell Functional Manifolds

We asked whether retinal ganglion cells (RGCs) possess a locally organized intrinsic spatiotemporal speed scalethat is reproducible across vertebrate species. For each RGC, a characteristic scale was defined as v* =sigma/tau, where sigma denotes a receptive-field spatial scale an...

Canalization of Retinal Electrophysiological Failure and Recovery:A Multi-Cohort State-Space Analysis of PERG and Full-Field ERG

Objective: To test whether retinal electrophysiological dysfunction exhibits a low-dimensional canalization geometry: larger departures from a normative state are accompanied by smaller angular deviation from a shared failure direction, and whether recovery after an intervention...

From Injury Canalization to Molecular Rescue: A Human-Derived Retinal Ganglion Cell State Space Predicts Optic Nerve Injury and Treatment Response

Background: Retinal ganglion cell (RGC) injury is typically analyzed by cell type, differential expression, or treatment-specificregeneration programs. A complementary question is whether injury and therapeutic response occupy a common molecularstate space that can be specified i...

A Universal Minimax Lower Bound for Causal Lagrangian TrackingFrom empirical flow-family classification to an algorithm-independent impossibility certificate with object-shape-aware tolerance

We develop a deterministic minimax lower bound for causal tracking of a Lagrangian object across an observation gap. Earlier work in this project identified an empirical dimensionless coordinate, Pi_U, that organized synthetic tracking difficulty across multiple flow families. Th...

Transient Optical Detection Transition Revisited Why the geometric reanalysis is stronger than the original pilot result - while remaining a model-defined detectability study

The original Transient Optical Detection Transition (TODT) pilot study reported that a physically present falling quartzobject entered a brief model-defined subthreshold state in a natural indoor scene. In the strict observer model, frames430-442 were classified as VISIBLE, frame...

Transient Optical Detection Transition Revisited Why the geometric reanalysis is stronger than the original pilot result - while remaining a model-defined detectability study

The original Transient Optical Detection Transition (TODT) pilot study reported that a physically present falling quartzobject entered a brief model-defined subthreshold state in a natural indoor scene. In the strict observer model, frames430-442 were classified as VISIBLE, frame...

A Universal Minimax Lower Bound for Causal Lagrangian TrackingFrom empirical flow-family classification to an algorithm-independent impossibility certificate with object-shape-aware tolerance

We develop a deterministic minimax lower bound for causal tracking of a Lagrangian object across an observation gap. Earlier work in this project identified an empirical dimensionless coordinate, Pi_U, that organized synthetic tracking difficulty across multiple flow families. Th...

Energy-Neutral Exact-Local Cascade Control in a Three-Dimensional Spectral Flow Solver

This study introduces the EIDOS Energy-Neutral Exact-Local Cascade (EN-ELC), a numerical spectral-feedback operator designed to alter resolved interscale energy transfer without directly adding net instantaneous kinetic-energy power to the fluid as a whole. The method is implemen...