Lauren Coombe

ntRoot : Genetic Ancestry Inference Across Diverse Genomic Data Types

Abstract Genetic ancestry is encoded in our genomes, reflecting the genealogical history of individuals and populations. This information is increasingly recognized as an important variable in large‐scale population studies, where it is used to correct for population stratificati...

Regulation of Osmotic Stress by OmpC but not OmpF Increases Kanamycin Resistance in Escherichia coli

Changing the ratio of outer membrane proteins, OmpF and OmpC, is a mechanism by which Escherichia coli are able to develop antibiotic resistance. Osmotic stress is known to affect the outer membrane protein ratio by increasing OmpC and decreasing OmpF expression. Our study assess...

ntSynt-viz: Visualizing synteny patterns across multiple genomes

Abstract With the explosion of chromosome-scale genome assemblies being generated in recent years, there is vast potential for comparative genomics analyses through detecting multi-genome synteny. While existing tools can detect synteny blocks between multiple genomes, their text...