Лагода

THEORY OF OBJECTS. ARTICLE 27. ATLAS 150 FOODS: PP/IT PROFILES FOR BIOAVAILABILITY

This article presents an atlas of 150 foods in the format of PP/IT profiles, taking into account the principle of bioavailability. According to this principle, only those beneficial molecules that actually reach the meta-compartments of the body are taken into account in the PC,...

THEORY OF OBJECTS. ARTICLE 16 . 14 META-COMPARTMENT: MUCOUS SECRETIONS OF THE RESPIRATORY TRACT. MUCOUS SECRETIONS OF THE RESPIRATORY TRACT AS A PROTECTIVE BARRIER OF THE LUNGS: PP/IT PROFILE AND RESTORATION OF METABOLIC DIVERSITY IN PEOPLE 55+

The mucous secretions of the respiratory tract are a complex biological environment containing defensins, secretory IgA, mucins, antimicrobial peptides, cytokines, and microbiota products that provide protection for the respiratory system. After the age of 55, the metabolomic div...

THEORY OF OBJECTS. ARTICLE 18. 16 META-COMPARTMENT: AMNIOTIC FLUID. AMNIOTIC FLUID AS A MEDIUM OF METABOLIC PROGRAMMING

Amniotic fluid is a complex biological environment that surrounds the fetus and provides it with nutrition, protection, movement, and metabolic programming. In the context of late pregnancy or analysis of the mechanisms of aging, the metabolomic diversity of amniotic fluid decrea...

THEORY OF OBJECTS. ARTICLE 9. 7 META-COMPARTMENT: CEREBROSPINAL FLUID (CEF). CEREBROSPINAL FLUID AS A PROTECTIVE ENVIRONMENT OF THE BRAIN: PP/IT PROFILE AND RESTORATION OF METABOLOMIC DIVERSITY IN PEOPLE 55+

Cerebrospinal fluid (CSF) is a medium that bathes the brain and spinal cord, providing neuroprotection, removal of metabolic waste, and transport of signaling molecules. After the age of 55, the metabolomic diversity of CSF decreases dramatically: the number of detectable metabol...

THEORY OF OBJECTS. ARTICLE 9. 7 META-COMPARTMENT: CEREBROSPINAL FLUID (CEF). CEREBROSPINAL FLUID AS A PROTECTIVE ENVIRONMENT OF THE BRAIN: PP/IT PROFILE AND RESTORATION OF METABOLOMIC DIVERSITY IN PEOPLE 55+

Cerebrospinal fluid (CSF) is a medium that bathes the brain and spinal cord, providing neuroprotection, removal of metabolic waste, and transport of signaling molecules. After the age of 55, the metabolomic diversity of CSF decreases dramatically: the number of detectable metabol...

THEORY OF OBJECTS. ARTICLE 14. 12 META-COMPARTMENT: SKIN SECRETIONS (SWEAT AND SEBACEOUS SECRETIONS). CUTANEOUS SECRETIONS AS A BARRIER META-COMPARTMENT: PP/IT PROFILE AND RESTORATION OF METABOLIC DIVERSITY IN PEOPLE 55+

Skin secretions — sweat and sebaceous secretions — form a complex metabolic environment containing pheromones, antimicrobial peptides, electrolytes, lipids, amino acids, and skin microbiota products. After the age of 55, the metabolomic diversity of skin secretions decreases dram...

THEORY OF OBJECTS. ARTICLE 7. 5 META-COMPARTMENT: LYMPH. LYMPH AS AN IMMUNE-METABOLIC BRIDGE: PP/IT PROFILE AND RESTORATION OF LYMPHATIC DIVERSITY IN PEOPLE 55+

Lymph is an intermediate link between the interstitium and the blood, providing transport of lipids, immune cells, and metabolites. After the age of 55, the metabolomic diversity of lymph decreases dramatically: the number of detectable metabolites drops from 3000–4000 to a criti...

THEORY OF OBJECTS. ARTICLE 18. 16 META-COMPARTMENT: AMNIOTIC FLUID. AMNIOTIC FLUID AS A MEDIUM OF METABOLIC PROGRAMMING

Amniotic fluid is a complex biological environment that surrounds the fetus and provides it with nutrition, protection, movement, and metabolic programming. In the context of late pregnancy or analysis of the mechanisms of aging, the metabolomic diversity of amniotic fluid decrea...

THEORY OF OBJECTS. ARTICLE 8. 6 META-COMPARTMENT: URINE SECONDARY. SECONDARY URINE AS AN INTEGRAL MARKER OF METABOLIC AGING: PP/IT PROFILE AND RESTORATION OF METABOLOMIC DIVERSITY IN PEOPLE 55+

Secondary urine is the final product of excretion, reflecting the metabolic diversity of the entire body. After the age of 55, the metabolomic diversity of urine decreases sharply: the number of detected metabolites drops from 2650–3100 to a critical threshold of less than 1000,...

SUBJECT THEORY: A NEW PARADIGM OF NUTRITION AND HEALTH. ARTICLE 1. BIOLOGICAL BASIS, META-COMPARTMENTS, PARAMETER VECTOR AND NEED FOR CONTROL

Nutrition determines up to 70% of the state of health, but there is still no fundamental scientific theory explaining the mechanism of this influence. Modern dietetics evaluates food mainly by its calorie content and macronutrient content, ignoring tens of thousands of molecular...

MOLECULAR ATLAS OF AGING. META-GROUP 20. ELECTROLYTES AND ION HOMEOSTASIS: A FUNDAMENTAL SHIFT THAT MAKES THE BODY "SALTY" AND BRITTLE. INTEGRATIVE APPROACH IN THE CONTEXT OF THE THEORY OF META-ENVIRONMENTS AND META-REGULATORS

Relevance. Electrolytes and ion homeostasis are the physicochemical foundation of life, on which all other biological processes are built. Sodium, potassium, calcium, magnesium, chlorine, and phosphates create membrane potential, control muscle contraction, regulate heart functio...

MOLECULAR ATLAS OF AGING. META-GROUP 16. HORMONES AND NEUROENDOCRINE REGULATION: A CONDUCTOR WHO LOSES CONTROL. INTEGRATIVE APPROACH IN THE CONTEXT OF THE THEORY OF META-ENVIRONMENTS AND META-REGULATORS

Relevance. The hormonal system is the main regulator of metabolism, growth, reproduction, stress response, and homeostasis. In youth, it works as a well-coordinated ensemble: cortisol and insulin accurately dose energy, leptin and adiponectin regulate appetite and fat metabolism,...

MOLECULAR ATLAS OF AGING. META-GROUP 20. ELECTROLYTES AND ION HOMEOSTASIS: A FUNDAMENTAL SHIFT THAT MAKES THE BODY "SALTY" AND BRITTLE. INTEGRATIVE APPROACH IN THE CONTEXT OF THE THEORY OF META-ENVIRONMENTS AND META-REGULATORS

Relevance. Electrolytes and ion homeostasis are the physicochemical foundation of life, on which all other biological processes are built. Sodium, potassium, calcium, magnesium, chlorine, and phosphates create membrane potential, control muscle contraction, regulate heart functio...

MOLECULAR ATLAS OF AGING. META-GROUP 22. EPIGENETIC MARKERS AND REGULATORS OF GENE EXPRESSION: THE CHRONOGRAPH OF AGING RECORDED AT THE MOLECULAR LEVEL. INTEGRATIVE APPROACH IN THE CONTEXT OF META-MEDIUM THEORY AND META-REGULATORS

Relevance. Epigenetic markers and regulators of gene expression are a chronograph of aging, recording every event of age-related degradation at the molecular level. DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs make up the epigenetic code that...

MOLECULAR ATLAS OF AGING. META-GROUP 14. COMPLEMENT SYSTEM: TWO-FACED JANUS, PROTECTING AND DESTROYING AT THE SAME TIME. INTEGRATIVE APPROACH IN THE CONTEXT OF THE THEORY OF META-ENVIRONMENTS AND META-REGULATORS

Relevance. The complement system is a cascade of more than 50 plasma and tissue proteins that provides rapid protection against pathogens, the removal of damaged cells, and the connection between innate and adaptive immunity. In youth, it works as a verified mechanism: it recogni...

MOLECULAR ATLAS OF AGING. META-GROUP 10. RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM AND VASOACTIVE PEPTIDES: LATENT DICTATOR OF PRESSURE AND FIBROSIS. INTEGRATIVE APPROACH IN THE CONTEXT OF META-MEDIUM THEORY AND META-REGULATORS

Relevance. The renin-angiotensin-aldosterone system (RAAS) is a hormonal system that regulates blood pressure, water-salt balance, and vascular tone. In youth, it works as a precise tool for maintaining homeostasis. However, with age, under the influence of inflammation, oxidativ...

MOLECULAR ATLAS OF AGING. META-GROUP 8. NEUROTROPHINS: THE ARCHITECTS OF THE BRAIN THAT LEAVE US WITH AGE. INTEGRATIVE APPROACH IN THE CONTEXT OF META-MEDIUM THEORY AND META-REGULATORS

Relevance. Neurotrophins are a family of small proteins critical for the survival, development, differentiation, and maintenance of neuronal function. They provide synaptic plasticity, learning, memory, and neuroprotection. Without them, the brain cannot renew, adapt, and recover...

MOLECULAR ATLAS OF AGING. META-GROUP 8. NEUROTROPHINS: THE ARCHITECTS OF THE BRAIN THAT LEAVE US WITH AGE. INTEGRATIVE APPROACH IN THE CONTEXT OF META-MEDIUM THEORY AND META-REGULATORS

Relevance. Neurotrophins are a family of small proteins critical for the survival, development, differentiation, and maintenance of neuronal function. They provide synaptic plasticity, learning, memory, and neuroprotection. Without them, the brain cannot renew, adapt, and recover...

MOLECULAR ATLAS OF AGING. META-GROUP 6. NEUROTROPHINS (BDNF, NGF, NT-3, GDNF): COGNITIVE DEATH. WITHOUT THEM, DEMENTIA, DEPRESSION, LOSS OF PLASTICITY. INTEGRATIVE APPROACH IN THE CONTEXT OF META-MEDIUM THEORY AND META-REGULATORS

Relevance. In the hierarchy of 22 groups of molecules affected by aging, neurotrophins occupy the sixth place — after gas transmitters (energy foundation), rejuvenation signaling proteins (regeneration architects), pro-inflammatory cytokines (chronic inflammatory fire), exogenous...

MOLECULAR ATLAS OF AGING. META-GROUP 4. EXOGENOUS XENOBIOTICS: AN ANTHROPOGENIC SHOCK ACCUMULATING OVER DECADES. INTEGRATIVE APPROACH IN THE CONTEXT OF META-MEDIUM THEORY AND META-REGULATORS

Relevance. In the hierarchy of 22 groups of molecules affected by aging, exogenous xenobiotics occupy the fourth place — after gas transmitters (energy foundation), rejuvenation signaling proteins (architects of regeneration) and pro-inflammatory cytokines (chronic inflammatory f...