Huiling Wang

Targeted microglial ROS-scavenging alleviates neuroinflammation and cognitive deficits via restoration of the 2-AG/CB2R signaling axis in schizophrenia

Cognitive impairment in schizophrenia is inadequately treated. The molecular link between oxidative stress and neuroinflammation in its pathophysiology remains unclear. We measured CB2R in circulating microglia‑derived exosomes from schizophrenia patients and healthy controls. In...

Adolescent environmental enrichment prevents early-life stress-induced schizophrenia-like phenotypes via restoration of CREB-BDNF-TrkB signaling

Early-life stress (ELS) is a major environmental risk factor for schizophrenia, yet effective preventive strategies targeting its neurodevelopmental consequences remain limited. Here, we show that adolescent environmental enrichment (EE) prevents the emergence of schizophrenia-li...