Huan Li

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene

Malignant hyperthermia (MH) is a life-threatening pharmacogenetic condition triggered by volatile anesthetics, which activate pathogenic RyR1 mutants. The small molecule therapeutic dantrolene has long been used to treat MH. However, the binding site and mechanism of dantrolene r...

Erasable PCM-Assisted Probe for In Situ Monitoringof Photonic Integrated Circuits

Abstract Photonic integrated circuits (PICs) are essential for modern optoelectronics, yet fabrication-induced random phase errors often necessitate precise detection and calibration before application. Optical probing offers a direct detection method before packaging. However, c...