Guillaume Bourque

Altered sperm DNA methylation provides an epigenetic route from overweight and older men to intergenerational disease transmission

The occurrence of childhood neurodevelopmental disorders has been steadily increasing for decades, yet we have little understanding of modes of inheritance implicated in these diseases. Epidemiology studies have revealed an association between an elevated paternal Body Mass Index...

The gene-regulatory evolution of the human skeleton

Abstract Skeletal modifications were central to human evolution, enabling adaptations for bipedalism, large cranial vaults and childbirth 1 . Despite their importance, the genetic changes that gave rise to the unique human form remain mostly unknown 2 . Here we systematically map...

TEExplorer: a web portal to investigate TE-epigenome associations across human cell types

Approximately half of the human genome is derived from transposable elements (TEs) and several studies support the involvement of TEs in genome regulation in development, immunity and disease. We previously leveraged 4614 ChIP-seq samples from the International Human Epigenome Co...