George Davey Smith

Dietary pattern and epigenetic aging: a longitudinal twin study

Diet is an environmental factor influencing aging and life expectancy. Age-associated DNA methylation and epigenetic clocks are primary hallmarks of aging and may be modified by diet. However, observed associations between diet and epigenetic clocks may be confounded by familial...

Antihypertensive Treatment and Risk of Metabolic Associated Fatty Liver Disease: A Drug-Target Mendelian Randomization

BACKGROUND: Metabolic dysfunction-associated fatty liver disease, conventionally known as nonalcoholic fatty liver disease (NAFLD), affects over a quarter of the global population and lacks approved pharmacological treatments. We investigated whether elevated blood pressure (BP)...

Evaluating the consequences of childhood adiposity on the human plasma proteome at four timepoints across the lifecourse

Abstract Applying a lifecourse approach using human genetic data, we evaluate the effect of childhood adiposity on the circulating proteome using measurements taken at four key life stages. Using lifecourse Mendelian randomization, we find genetically predicted childhood adiposit...

Robust inference and correlates from genetic associations with personality

Personality traits describe stable differences in how people think, feel and behave, and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustne...

Effects of maternal and paternal smoking on offspring cardiometabolic risk factors in adulthood: a multi-method intergenerational Mendelian randomization study

Abstract Background Parental smoking has been linked to several adverse offspring cardiometabolic outcomes; however, evidence is conflicting regarding the causal and long-term nature of these associations. Methods We investigated the effects of maternal and paternal smoking, capt...