Gagandeep Kaur

Characterizing the B-cell senescence signature in driving the disease phenotype in COPD/emphysema

Increased cellular senescence is a key mechanism underlying chronic inflammation and airway remodeling in chronic obstructive pulmonary disease (COPD). Yet, the cellular composition and molecular features of the senescent microenvironment in COPD remain poorly understood. To addr...

Mapping Cellular Senescence, Cellular Plasticity, and Alveolar Niche Heterogeneity in Human Lung Development

This repository contains the code, workflows, and source files used for the analyses presented in the manuscript. Contents Preprocessing and integration of pediatric lung snRNA-seq datasets Harmony integration and Azimuth annotation workflows Cell proportion analyses Differential...