Chaoguang Tian

Semi-automated strain engineering and screening in the thermophilic fungus Myceliophthora thermophila for recombinant protein production

ABSTRACT Thermophilic filamentous fungi are widely used for cellulase production at elevated temperatures; however, efficient recombinant protein production in these organisms remains limited because construction and screening of large transformant populations remain difficult. H...

Unlocking raw-corncob consolidated bioprocessing for malic acid production by DyP-enabled lignin deconstruction in Myceliophthora thermophila

l -Malic acid is an important C4 platform chemical, but its direct production from raw lignocellulosic biomass by consolidated bioprocessing (CBP) remains constrained by biomass recalcitrance. Here, we developed an integrated lignin-side and sugar-side engineering strategy in the...