Celeste M M. Karch

MAPT mutations are associated with rDNA transcriptional hyperactivation and nucleolar stress in cellular models

Abstract Tau is traditionally known for its role in microtubule stabilisation, with its pathological aggregation central to tauopathies such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Recent evidence suggests that tau also plays important nuclear and nucleolar...