The Response of Extensive Fungal Infections of the Soles of Feet, Palms, and Nails to Low-Dose Food-Grade Hydrogen Peroxide: A Case Report

Abstract

Background: Due to its growing resistance to treatment, dermatophytosis remains a major global health challenge. Recent case reports of tinea unguium resolution using low-dose food-grade hydrogen peroxide (FGHP) in two patients with 25- and 52-year histories of the disease suggest that FGHP could be effective for managing dermatophytosis. The present case report supports that view. Method: A 45-year-old woman with dermatophytosis involving the palms, soles, web spaces, and nails was prescribed 40 mL of 0.5% FGHP thrice daily for one month, followed by 40 mL of 1% FGHP thrice daily for the second month, and 40 mL of the 0.5% FGHP again for the third month. Three cycles of this therapy were administered, with one-month therapy-free intervals. Additionally, 3% off-the-counter hydrogen peroxide was applied daily to extensive sole ulcers. Results: By the end of the first therapy cycle, all dystrophic nails shed. Dermatophytosis cleared during the third cycle, and new nails were formed by the end of twelve months. The sole ulcers healed two months later. Brief nausea was noted as an adverse effect. Conclusion: This study emphasises the potential benefits of low-dose FGHP in managing dermatophytosis and the need to determine its appropriate dose and safety profile.