Biologyarticle2026-10-12

To Explore Human H1 Histamine Receptor (H1R) Active Sites

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Abstract

Abstract-The human H1 receptor (H1R) is G-protein-coupled receptor.The histamine,biogenic amine, canoccupy the H1R and activates the H1R-histamine complex, responsiblefor producing biological activity like triple responses (flush, flare and wheel), allergy,urticaria, gastric stimulation, increase cardiac activity etc. Theexploration of histaminereceptor at molecular level is urgent for better understanding the biochemical mechanismsand structure function relationship of H1R.

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View paper (DOI)Open access version OpenAlexZenodo (CERN European Organization for Nuclear Research)Published 2026-10-12

Authors: Sandhya Dharkiya, Deepak Teotia, Sisir Nandi

Computational Drug Discovery Methods Mast cells and histamine Receptor Mechanisms and Signaling