Anxiety and Depression in Cervical Cancer Patients in Relation to Nutritional Status and Oxidative Stress

Abstract

Cervical cancer remains a major global health concern, causing substantial morbidity and mortality, particularly in low- and middle-income countries. Beyond its physical burden, patients frequently experience significant psychological distress, including anxiety and depression, which can adversely affect treatment adherence, daily functioning, and overall quality of life. Emerging evidence highlights the intricate relationships between psychological well-being, nutritional status, and oxidative stress in this population. Malnutrition and cancer cachexia may exacerbate fatigue, cognitive dysfunction, and emotional vulnerability, while oxidative stress contributes both to disease progression and neuropsychological disturbances. This narrative review synthesizes current research on anxiety and depression in cervical cancer patients, emphasizing how impaired nutritional status and elevated oxidative stress are associated with increased psychological burden. Understanding these interconnections is essential for developing comprehensive, multidisciplinary interventions that address both somatic and emotional health, optimize patient outcomes, and improve quality of life.