Catalytic Desymmetrizing Carbonyl–Amine Condensation Reaction to Construct Axially Chiral Diaryl Ethers
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Abstract
Abstract Catalytic desymmetrizing carbonyl–amine condensation (CAC) reactions between prochiral 2,6-diamino diaryl ethers and cyclobutane-1,3-diones have been developed for the highly enantioselective synthesis of axially chiral diaryl ethers in up to 99% ee values. This reaction represents the first application of prochiral aromatic amines in catalytically asymmetric CAC reactions. Control experiments revealed that cyclobutane-1,3-diones showed an obviously higher reactivity and enantioselectivities in these asymmetric CAC reactions.
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Authors: Tao Huang, Ze-Xin Zhou, Hui-Ling Zhou, Xu-Ping Liu, Yanfei Niu, Yiyuan Peng, Qiuping Ding, Xing‐Ping Zeng
Institutions: East China Normal University, Jiangxi Normal University