Biologyarticle2026-09-24

Culture‐Negative Infective Endocarditis Presumed due to Brucella Causing Rapid Native Aortic Valve Destruction in a Young Adult: A Case Report

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Abstract

ABSTRACT Culture‐negative endocarditis with features consistent with Brucella can rapidly destroy a normal aortic valve in young adults. 2023 Duke‐ISCVID criteria (clinical/imaging findings plus histopathology), supported by serology and occupational exposure enabled urgent combined antimicrobial‐surgical management without culture confirmation, highlighting the need for high suspicion and early intervention in endemic regions.

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View paper (DOI)Open access versionOpenAlexClinical Case ReportsPublished 2026-09-24

Authors: Baraa Nassar, Kristen I. Gharo, Olga Sallam Ramahi, Hussein Ghannam, Ahmed Romana, Kinda Abu Hashhash

Institutions: Palestine Polytechnic University, Al-Quds University, Palestinian Hydrology Group