Cycloserine inhibits glutamate decarboxylase from Mycobacterium tuberculosis
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Abstract
. Both cycloserine enantiomers break the internal aldimine bond between PLP and the conserved Lys277 residue, forming a previously unrecognised PLP-oxime product and subsequently inhibiting catalysis. Given that PLP-dependent enzymes are promising drug targets, understanding the chemical behaviour of PLP is essential for developing selective inhibitors.
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View paper (DOI)Open access versionOpenAlexJournal of Enzyme Inhibition and Medicinal ChemistryPublished 2026-09-21
Authors: Jan Snášel, Jiří Dostál, Michal Tupec, Ondřej Bulvas, Iva Pichová
Institutions: Czech Academy of Sciences, Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry