Single-cell multi-omics landscape of mouse embryogenesis

Abstract

we present a paired single-cell dual-omics atlas of mouse embryogenesis using HT-scCAT-seq, capturing joint transcriptome and chromatin-accessibility profiles across five stages (E8.5-E12.5), this cell-type-resolved resource establishes a quantitative framework for understanding lineage specification, organogenesis timing, and the regulatory origins of congenital disease.