A Highly Robust Y‐Based Framework for Sustainable Catalysis and Synthesis of Bioactive Chromeno[2,3‐ d ]Pyrimidin‐8‐Amine Derivatives

Abstract

ABSTRACT The synthesis of bioactive molecules through one‐pot multicomponent reactions under mild conditions is of significant interest for medicinal chemistry, though largely unexplored and challenging. Herein, we have reported a new Y(III)‐based chemically stable framework, IITKGP‐65, with abundant active catalytic sites, which exhibited excellent stability in open air, water, and even in acidic medium. The activated framework, IITKGP‐65a , has been utilized as a Lewis acid‐driven heterogeneous catalyst for the synthesis of bioactive chromeno[2,3‐ d ]pyrimidin‐8‐amine derivatives. Notably, synthesis of these compounds has not yet been reported in the literature using any coordination polymer (CP) or metal–organic framework (MOF)‐based catalyst. Interestingly, a good to excellent yield was achieved even with a low catalyst loading of our developed catalyst for a wide range of substrate scopes, along with excellent recyclability without any loss of structural integrity. Most importantly, to demonstrate practical applicability, we synthesized four chromeno[2,3‐ d ]pyrimidin‐8‐amine derivatives exhibiting antibacterial activity using a green ethanol medium. The facile accessibility, robust structural framework, outstanding catalytic performance, and excellent recyclability collectively underscore the potential of the developed framework, IITKGP‐65 , as an efficient catalyst. Furthermore, these attributes extend its applicability to the environmentally friendly synthesis of complex bioactive molecules.