Application of Isatoic Anhydride‐Modified Ceramic Catalytic Membrane in the C 2 ‐Arylation of Indoles

Abstract

Using isatoic anhydride and KH550, a recyclable Pd‐loaded ceramic catalytic membrane was developed. Systematic investigation of loading temperature on silane coupling agent growth (using Pd content as criterion) identified 90 °C as optimal. The Pd‐ABA‐KH550‐CM‐90 membrane showed stable catalysis over 12 cycles without Pd leaching, high activity in gram‐scale drug synthesis, highlighting its potential for sustainable catalysis.