Biologyarticle2026-08-23

Regenerative Capacity and the Limit of Viability Recovery: Resources, Damage, and Conditions for System Return

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Abstract

This article proposes a metrological model of regenerative capacity and the limit of viability recovery in systems of different kinds. The approach continues the metrological apparatus developed in G17–G24 and builds upon established research on biological regeneration, physiological reserve, stem-cell function, injury response, inflammation, metabolism, and age-related decline in restorative potential. Contemporary research shows that regenerative capacity differs substantially among species, organs, types of damage, and age-related states [1–4]. It depends not only on damage magnitude, but also on cellular sources of regeneration, microenvironment, immune response, metabolic support, tissue structure, and previous system history [1–6]. G25 proposes distinguishing current regenerative capacity, regenerative reserve, and recovery limit. The article formulates the proposition that equal observable damage does not imply equal recoverability. The working concepts of Recovery Limit, Regenerative Window, Regenerative Resource Sufficiency, Reserve-to-Damage Ratio, and Irrecoverable Transition under Defined Conditions are introduced. The central hypothesis is that the recovery limit is determined not by one cause, but by the configuration of the relation among damage, preserved viability architecture, available resources, resource-transformation capacity, regenerative reserve, and environmental conditions. Falsifiability criteria and a cross-class measurement protocol are proposed. Keywords: Vitology, viability, regenerative capacity, recovery limit, regenerative reserve, damage, recoverability, viability boundary, physiological reserve, regenerative window.

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View paper (DOI)Open access versionOpenAlexZenodo (CERN European Organization for Nuclear Research)Published 2026-08-23

Authors: Serhii Hostiunin