P1.007. Gender-Related Differences in Eosinophilic Esophagitis: Analysis of a 22-Year Population-Based Observational Study From Southwest Sweden

Abstract

Abstract Topic Benign Disease: Eosinophilic Esophagitis Background Apart from a distinct male predominance, gender differences in eosinophilic esophagitis have been scarcely explored. The aim of the present study was to investigate potential gender-related factors in a previously described Swedish long-term cohort. Methods Medical records between 2000 and 2022 in patients fulfilling the diagnostic criteria of EoE in the catchment area of Northern Älvsborg County Hospital (NÄL) were studied. Factors including coexisting allergy, atopic disorder, asthma, GERD, IBD, food impaction, trachealisation, strictures and esophageal cancer were analysed using Fishers exact test (significance level p<.05). Results A total of 409 patients (74% males, n=302) were eligible for inclusion in the analysis. The median age was 48 years (2-83) in females and 39 (1-88) in males. Concurrent allergy was found to be more common in males (58%) compared to in females (49%, p=.018). In addition, the occurrence of one or more previous episodes of acute food impaction was more common in males (64% vs 47%, p=.002). No other gender-related differences were found for the factors included. Conclusion A few significant gender-related dissimilarities were found in the present setting. Whether these are caused by a gender-differentiated level of care, a variation in eating habits or by diverse subtypes of the disease should be further investigated.