FORMULATION & EVALUATION OF 1% OZENOXACIN EMULGEL FOR THE TREATMENT FOR BACTERIAL DISEASE

Abstract

AbstractTopical antibiotics represent an effective strategy for localized treatment of bacterial infections,minimizing systemic exposure and side effects. This study was designed to formulate andevaluate a 1% Ozenoxacin emulgel, a promising new treatment option for bacterial skinconditions. Three formulations were prepared using different gel-forming agents - Carbopol 934,Carbopol 940, and Hydroxypropyl Methylcellulose (HPMC), with each formulation evaluatedfor viscosity, spreadability, extrudability, and in vitro drug release.Formulation C (HPMC) exhibited the highest viscosity (240±8 cP), which correlated with slowerdrug release, achieving 80% release after 8 hours. Formulation B (Carbopol 940) displayedoptimal spreadability (9±0.8 cm) and extrudability (1.6±0.05 g), contributing to improved userapplication. Absorbance of Ozenoxacin was evaluated, with peak absorbance occurring at awavelength of 250 nm.This research underscores the significance of the choice of gel-forming agents in the formulationof emulgels, with clear implications for drug release rates and application properties. Furtherresearch is needed to refine these formulations and evaluate their therapeutic efficacy in vivo.