In vivo T‐cell depletion and pharmacokinetic‐based busulfan conditioning regimen improve the outcomes in acute myeloid leukemia (AML) in complete remission undergoing to allogeneic stem cell transplantation
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Abstract
Pharmacokinetic‐based busulfan administration improves the therapeutic window and in vivo T‐cell depletion with antilymphocyte globulins reduces graft‐versus‐host disease incidence. In this study, both were used, showing an improvement of clinical outcomes in patients with acute myeloid leukemia.
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Authors: Roberto Bono, Cristina Rotolo, Giuseppe Sapienza, Corinne Spoto, Carmelo Costanza, Sergio Indelicato, Caterina Patti, Antonino Mulè, Valeria Calafiore, Giulia Arrigo, Alessandra Santoro, Laura Noto, Luca Castagna
Institutions: University of Palermo, Ospedale Vincenzo Cervello