B‑cell activating factor gene polymorphisms rs9514828 and rs1041569 increase preeclampsia risk

Abstract

Aims This study investigated the association between BAFF gene polymorphisms (rs1041569 and rs9514828) and preeclampsia (PE) susceptibility in an Iranian population, with a focus on disease severity and onset timing.Patients and methods This case-control study included 560 pregnant women (280 with PE and 280 normotensive controls) from Zahedan, southeastern Iran. Genotyping was performed using PCR-RFLP. Associations were assessed using logistic regression to calculate odds ratios (ORs) with 95% confidence intervals (CIs).Results For rs9514828, the CT and TT genotypes were associated with increased PE risk (OR = 1.81, p = 0.011; OR = 2.13, p = 0.002). For rs1041569, the AT and TT genotypes were also associated with increased risk (OR = 1.48, p = 0.033; OR = 1.68, p = 0.037). Haplotype analysis revealed that the C-A haplotype was protective (OR = 0.69, p = 0.003), while the T-T haplotype showed similar protection (OR = 0.69, p = 0.003). All genotype distributions were in Hardy-Weinberg equilibrium in the control group.Conclusion BAFF polymorphisms are significantly associated with PE susceptibility in the Iranian population and may serve as potential biomarkers for PE risk assessment.