Geropsychosis: A Biophysical Framework for Understanding Psychiatric Symptoms as Accelerated Aging Pathologies

Abstract

The theory of geropsychosis reconceptualizes anxiety, mood, psychotic, and neurocognitive disorders as primarily emerging from the universal accumulation of metals, advanced glycation end products (AGEs), advanced lipoxidation end products (ALEs), and their hybrid complexes among post-pubescent individuals. These inputs drive self-reinforcing molecular feedback loops underlying clinically meaningful insults against the nervous system, thus extending the Conglomerate Theory of Aging to mental health. Through comprehensive analysis of molecular damage and neural function, we establish that psychiatric symptoms emerge from the same fundamental aging mechanisms that comprise systemic decline. This unified understanding provides a mechanistic foundation for reconceptualizing several mental disorders as emerging from similar sources rather than wholly disparate pathological routes. The geropsychosis framework thus reveals new therapeutic targets and intervention strategies that may directly address the fundamental causes of psychiatric pathology.