Evaluating Diagnostic Performance and Contamination Control in Nanopore Sequencing for Ocular Infections

Abstract

A scoping review mapping the primary literature on nanopore sequencing for the diagnosis of infectious keratitis, infectious keratoconjunctivitis and infectious endophthalmitis. The review will chart reported diagnostic performance against culture and molecular reference standards, appraise contamination-control and reporting practice across included studies, and identify methodological gaps informing evidence informed reporting recommendations for clinical use. Conducted following JBI methodology and reported according to PRISMA-ScR.