DEVELOPMENT AND CHARACTERIZATION OF AMLODIPINE LOADED SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM NEEDS FOR EFFECTIVE HYPERTENSION TREATMENT

Abstract

Through the development of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS), the current project aims to improve the oral bioavailability and therapeutic efficacy of amlodipine, a weakly water soluble hypertension medication. Tween 20 was used as the surfactant and peppermint oil as the lipid phase to create amlodipine-loaded SNEDDS. Using particle size and entrapment efficiency as response parameters, the Box-Behnken Design was utilized to optimize important formulation factors, such as oil content, surfactant ratio, and homogenization time. The optimized formulation (Batch A2) showed physical stability with a particle size of 90.6 nm, entrapment effectiveness of 98.05%, and zeta potential of –24.5 mV. High transparency, an 83°C cloud point, and advantageous drug release characteristics were found in characterization investigations. Similar to the common medication captopril, moderate antihypertensive efficacy was shown by in vitro ACE inhibition studies. The formulation's resilience over a month in a refrigerator was further confirmed by stability tests. The results of this study show that SNEDDS greatly increase the solubility, stability, and antihypertensive effectiveness of amlodipine, providing a viable method for the oral administration of lipophilic medications.