Research Briefs

Medicine · Oncology

Colorectal Cancer Screening and Detection

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Abstract editorial illustration accompanying the article: Trial reports how a blood test detected cancer signals in adults aged 50 and older
Health & Medicine
Moderate evidenceHuman study

Trial reports how a blood test detected cancer signals in adults aged 50 and older

Researchers studied a blood-based test designed to identify signals of several cancers and suggest where a cancer might be located. Among adults aged 50 and older without a clinical suspicion of cancer, the test detected a cancer signal in 0.54% of performance-analyzable participants, and 60.3% of positive results were linked to a confirmed cancer. The study measured test performance and safety, not whether screening improves health outcomes.

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Health & Medicine
High evidenceHuman study

Trial reports how a blood test performed in screening for several cancers

Researchers analyzed performance data from the human NHS-Galleri randomized trial, which included 142,250 adults aged 50–77. The multi-cancer early detection test produced positive results in about 0.8% to 1.0% of participants per screening round, but the study’s primary goal—reducing diagnoses of advanced cancer—was not met.

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Abstract editorial illustration accompanying the article: Researchers report strong performance from an AI model for stomach biopsy images
AI & Computing
Moderate evidenceHuman study

Researchers report strong performance from an AI model for stomach biopsy images

In a large human, multicenter cohort study, researchers developed and tested an artificial intelligence model for classifying stomach biopsy images. The model showed high reported accuracy in external and prospective testing and improved nine pathologists’ results in an auxiliary experiment, but the study did not establish effects on patient outcomes or performance in every clinical setting.

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