Zucker Hillside Hospital

Identification of robust speech-based markers of negative symptom severity in schizophrenia spectrum disorders

There is growing interest in using digital health technologies to overcome limitations of traditional negative symptom assessment in schizophrenia spectrum disorders (SSD). For example, computerized speech analysis has been used to quantify speech and language changes associated...

A critical review of the early clozapine trials published in German and a discussion of the many unresolved issues left by these trials

Clozapine was (1) first introduced in Austria and Switzerland in 1972, (2) associated with 8 Finnish deaths due to agranulocytosis in 1975 (almost leading to its withdrawal), and (3) approved in the United States (US) for treatment-resistant schizophrenia in 1989 (resulting in a...