Zigong First People's Hospital

Shared genetic architecture underlying cataract and cardiovascular disease: insights from multi-omics analyses

Abstract Cataract and cardiovascular disease (CVD) are prevalent age-related disorders with overlapping risk factors. While epidemiological associations are established, the shared genetic mechanisms underlying their comorbidity remain largely unexplored. We performed a comprehen...

Inflammation-associated hsa_circ_0054391 regulates epithelial-mesenchymal transition and vasculogenic mimicry in colorectal cancer via the miR-1252-3p/VEGFA/ZEB1 axis

Abstract To define the functional role of hsa_circ_0054391 (circ54391) in CRC progression and to evaluate its potential as a serum biomarker. Circ54391 was identified from databases and its expression was validated in CRC tissues, cell lines, and serum from healthy controls ( n =...

GCCA-trans: a hybrid segmentation network with guided criss-cross attention for early-stage head and neck tumors in CT images

Accurate lesion segmentation in medical images is essential for disease assessment and treatment planning. Most head and neck tumors can be clinically cured when treated at an early stage, making early detection highly beneficial for guiding effective therapy. However, research o...

Triaptosis-related prognostic model for lung adenocarcinoma based on transcriptomic analysis and experimental validation

Abstract Background The role of triaptosis, as a novel form of regulated cell death (RCD), remains poorly understood in lung adenocarcinoma (LUAD). This study scout to identify triaptosis-related prognostic genes in LUAD and construct a prognostic model. Methods Triaptosis-relate...

Janibacter melonis bone marrow infection in an immunocompetent child with prolonged fever of unknown origin: a case report

Abstract Introduction Janibacter melonis ( J. melonis ) is a rare environmental actinomycete with only three previously reported human infections, all presenting as bacteraemia — all in adults, two of whom were immunocompetent and one of whom had refractory diffuse large B-cell l...

Comparison of the efficacy of self-gripping mesh and sutured mesh in lichtenstein inguinal hernia repair: a meta-analysis and GRADE assessment

Lichtenstein inguinal hernia repair is a common surgical procedure. Self-gripping mesh, a novel mesh that does not require suturing, has emerged as a potential alternative to traditional sutured mesh. This study aimed to evaluate the efficacy differences between self-gripping and...

Symptom heterogeneity and factors associated with dignity-related distress in older adults with incontinence-associated dermatitis

To identify latent symptom profiles of dignity-related distress among older adults with incontinence-associated dermatitis (IAD) and to explore the associated sociodemographic and clinical factors, aiming to inform targeted care strategies. A cross-sectional study was conducted f...

Malignant adenomyoepithelioma of the breast with contralateral homologous tumor and ductal carcinoma in situ: two case reports

Introduction and importance: Malignant adenomyoepithelioma (MAME) is a rare biphasic breast tumor with no standardized management guidelines. Co-occurrence with other breast malignancies is extremely rare. Case introduction: We report two cases with long-term follow-up: a 59-year...

A machine learning model based on mPASS and imaging features for early assessment of clinically relevant outcomes in acute pancreatitis

To develop and validate a machine learning (ML) model based on the modified pancreatitis activity scoring system (mPASS) and imaging features for the early assessment of multiple clinically relevant outcomes in acute pancreatitis (AP). A retrospective cohort of 420 AP patients wa...

Squamous papilloma of the external ear in Southwest China: A large case series highlighting predominant HPV subtypes, pathologic features, and unique epidemiologic factors.

Squamous papilloma (SP) of the external ear is a rare benign neoplasm, with limited research on its associated human papillomavirus (HPV) infections and pathologic features. This study aims to provide a comprehensive analysis of the largest case series of external ear SP from Sou...

Integrative analysis of network pharmacology and machine learning suggests potential anti-colorectal cancer mechanisms of Taohong-Siwu decoction

Colorectal cancer (CRC) remains one of the most prevalent malignancies worldwide, characterized by high morbidity and poor prognosis. Although traditional Chinese herbal formulas have shown promising therapeutic potential, their multi-target mechanisms in CRC are still poorly und...