Ziauddin Hospital

Early best available antibiotic therapy for multidrug-resistant gram-negative bloodstream infections: a target trial emulation

Background The effect of timely appropriate antibiotics in multidrug-resistant Gram-negative bacteria (MDR-GNB) bloodstream infections (BSIs) remains uncertain. Robust evidence is needed to inform diagnostic and treatment strategies, especially across settings with high antimicro...

Comparative Effectiveness and Safety of Denosumab Versus Bisphosphonates in the Management of Osteoporosis: A Systematic Review and Meta-Analysis

Osteoporosis is a widespread bone disorder, as the bone strength is decreased, bone microarchitecture deteriorates, and an increased risk of fragility fracture occurs, especially in the elderly and postmenopausal women. Anti-resorptive drugs, such as bisphosphonates and denosumab...

Comparative Effectiveness of Surgical and Non-Surgical Management of Pediatric Femoral Shaft Fractures: MetaAnalysis of Radiological Outcomes and Complications

ABSTRACT: Pediatric femoral shaft fractures can be managed using both surgical and non-surgical strategies, with treatment selection influenced by age, body weight, fracture stability, and associated injuries. This systematic review and meta-analysis aim to compare radiological,...

Comparative Effectiveness of Surgical and Non-Surgical Management of Pediatric Femoral Shaft Fractures: MetaAnalysis of Radiological Outcomes and Complications

ABSTRACT: Pediatric femoral shaft fractures can be managed using both surgical and non-surgical strategies, with treatment selection influenced by age, body weight, fracture stability, and associated injuries. This systematic review and meta-analysis aim to compare radiological,...