Zhujiang Hospital

Resveratrol reprograms ARG1⁺ microglia to remodel the immunosuppressive microenvironment in primary CNS lymphoma via secretion cytokine

Abstract Primary central nervous system lymphoma (PCNSL) is a CNS-restricted lymphoma with poor prognosis. Despite sharing pathological features with systemic diffuse large B-cell lymphoma (DLBCL), PCNSL exhibits unique molecular mutation patterns, highlighting the critical role...

Genetic etiology associated with post‑transplant outcomes in a retrospective cohort of pediatric kidney transplant recipients based on genomics analysis

To determine whether genetic etiology, as determined by whole-exome sequencing (WES) and copy-number variant (CNV) analysis, is associated with graft survival and early injury profiles in pediatric kidney transplant recipients. We conducted a single-center, retrospective cohort s...

Adolescent environmental enrichment prevents early-life stress-induced schizophrenia-like phenotypes via restoration of CREB-BDNF-TrkB signaling

Early-life stress (ELS) is a major environmental risk factor for schizophrenia, yet effective preventive strategies targeting its neurodevelopmental consequences remain limited. Here, we show that adolescent environmental enrichment (EE) prevents the emergence of schizophrenia-li...

Case report of rare complication: unilateral chest wall hematoma after intracranial aneurysm embolization

Unilateral chest wall hematoma is a rare but life-threatening cause of shock following endovascular procedures. We report a case of refractory hypotension and unilateral chest wall swelling in the post-anesthesia care unit, which was initially suspected to be a tension pneumothor...

Association between calling and work engagement, and the mediating role of psychological capital and organizational commitment: a structural equation modeling study in China

Abstract Purpose This research aimed to examine the association between calling and work engagement, as well as the mediating roles of psychological capital and organizational commitment. The findings may inform the development of targeted interventions to enhance work engagement...

Hemodynamic integration in extracorporeal membrane oxygenation anticoagulation

Despite progressive advances in circuit design, material biocompatibility, and anticoagulation monitoring, bleeding and thrombosis remain common during extracorporeal membrane oxygenation and are closely associated with adverse outcomes. Current practice still relies mainly on he...

Preliminary experience of mechanical thrombectomy treatment in pediatric arterial ischemic stroke: a retrospective case series

To evaluate the feasibility and efficacy of mechanical thrombectomy in the treatment of pediatric acute ischemic stroke (AIS). The clinical data, radiographic results and management outcomes of children diagnosed with AIS and treated at our hospital between 2016 and 2021 were ret...

Cross-KingdommiR5054 Delivery via Polygonum cuspidatum -Derived Nanoparticles Enhances Burn Wound Healingby Regulating Microvascular Environment

Abstract Deep partial-thickness burns are characterized by a self-perpetuating cycle of oxidative stress and inflammation that severely impedes healing. Here, we identified Polygonum cuspidatum-derived nanoparticles (PDNs) as a multifaceted nanotherapeutic that breaks this pathog...

Chondrosarcoma of the mobile spine: impact of tumor status at referral and surgical strategy on oncological outcome

BACKGROUND: Chondrosarcoma (CHS) is a rare malignant bone tumor, mostly histologically low grade, demonstrating limited response to chemotherapy and conventional photon radiotherapy (RT). According to Enneking Staging System, tumor-free margin en bloc resection is the cornerstone...