Zhujiang Hospital

Dynamic fund protection in markets with stochastic volatility and frictions: a double Heston model with transaction costs and its applications

This paper develops a pricing framework for Dynamic Fund Protection (DFP) contracts with lookback features under a double Heston stochastic volatility model with proportional transaction costs. The valuation leads to a multidimensional nonlinear partial differential equation (PDE...

Metabolic reprogramming for CAR-T cell therapy: advances and perspectives

Chimeric antigen receptor T cell (CAR-T) therapy has redefined the therapeutic landscape of hematological malignancies, yet its efficacy in solid tumors remains constrained by rapid functional attrition. Metabolic fitness serves as the primary arbiter of CAR-T cell fate, orchestr...

Single-cell analysis reveals immunotherapy-induced epithelial state remodeling and identifies PLAUR as a prognostic biomarker in colorectal cancer

Immune checkpoint blockade has achieved durable responses in a subset of colorectal cancer (CRC) patients; however, the majority derive limited benefit. While previous studies have largely focused on immune cell dynamics, how tumor epithelial cells adapt to immune selection press...

Surface-displayed cholesterol enhances penetration and anti-tumor activity of a platinum nanodrug by targeting NPC1L1-expressing cancer associated fibroblasts

Transcytosis-mediated delivery effectively enhances tumor penetration of nanodrugs but is less efficacious in stroma-rich tumors. Cancer associated fibroblasts (CAF) can represent a physical barrier for drug delivery in tumor cells. Herein, by selectively targeting NPC1L1-cancer...

Biomechanical comparison of three C2 subfacetal screw trajectories: a finite element analysis with reference to established posterior atlantoaxial fixation techniques

C2 subfacetal screw fixation has emerged as a crucial alternative for atlantoaxial instability when a high-riding vertebral artery (HRVA) precludes the use of conventional C2 pedicle screws. However, a comprehensive finite element analysis focusing on the biomechanical variances...

Prognostic value of circ_0049271 in NSCLC and its regulatory effect on tumor

To explore the prognostic significance and functional role of circ_0049271 in non-small cell lung cancer (NSCLC). Clinical data were meticulously collected from 140 patients diagnosed with NSCLC. Lung cancer tissues, along with adjacent normal tissues, were preserved at -80 °C. A...

Artificial intelligence in laboratory medicine: From machine learning to large language models

ABSTRACT: The integration of artificial intelligence (AI) into laboratory medicine has undergone a remarkable evolution over the past decade, shifting from traditional machine learning (ML) applied to structured laboratory data to the recent emergence of large language models (LL...

Rheum, Scutellaria, and Houttuynia effervescent tablets: a green strategy for controlling Vibrio parahaemolyticus outbreaks in aquaculture

BackgroundThe widespread misuse of antibiotics in aquaculture has led to severe drug resistance, threatening both industry sustainability and food safety. With increasing restrictions on antibiotic use, plant-derived antimicrobials have emerged as eco-friendly alternatives.Purpos...

Delayed diagnosis and genetic testing in spinal muscular atrophy: a case series

BACKGROUND: ) gene. Delayed diagnosis of SMA remains a common issue worldwide, particularly in regions with unequal medical resources. CASE PRESENTATION: Patient 1 was a 21-year-old man who had experienced limb weakness and muscle atrophy for 20 years. At the age of 6, he underwe...

Crosstalk Between CTSB + Glioblastoma Cells and S100A10 + Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

ABSTRACT Background : Glioblastoma (GBM) establishes a highly immunosuppressive microenvironment through intricate molecular dialogues with tumor‐associated macrophages (TAMs), contributing to immunotherapy resistance. Methods : We integrated advanced biological network analyses...

Trilobatin, a Natural Dihydrochalcone, Stabilizes Nrf2 to Protect the Heart from Angiotensin II–Induced Oxidative and Hypertrophic Stress

Aims: Oxidative stress–driven cardiac remodeling is a key pathological feature of heart failure and hypertensive heart disease, yet effective antioxidant therapies remain limited. This study aimed to determine whether the natural dihydrochalcone trilobatin (Tri) protects against...

Resveratrol reprograms ARG1⁺ microglia to remodel the immunosuppressive microenvironment in primary CNS lymphoma via secretion cytokine

Abstract Primary central nervous system lymphoma (PCNSL) is a CNS-restricted lymphoma with poor prognosis. Despite sharing pathological features with systemic diffuse large B-cell lymphoma (DLBCL), PCNSL exhibits unique molecular mutation patterns, highlighting the critical role...

Genetic etiology associated with post‑transplant outcomes in a retrospective cohort of pediatric kidney transplant recipients based on genomics analysis

To determine whether genetic etiology, as determined by whole-exome sequencing (WES) and copy-number variant (CNV) analysis, is associated with graft survival and early injury profiles in pediatric kidney transplant recipients. We conducted a single-center, retrospective cohort s...

Adolescent environmental enrichment prevents early-life stress-induced schizophrenia-like phenotypes via restoration of CREB-BDNF-TrkB signaling

Early-life stress (ELS) is a major environmental risk factor for schizophrenia, yet effective preventive strategies targeting its neurodevelopmental consequences remain limited. Here, we show that adolescent environmental enrichment (EE) prevents the emergence of schizophrenia-li...

Association between calling and work engagement, and the mediating role of psychological capital and organizational commitment: a structural equation modeling study in China

Abstract Purpose This research aimed to examine the association between calling and work engagement, as well as the mediating roles of psychological capital and organizational commitment. The findings may inform the development of targeted interventions to enhance work engagement...

Case report of rare complication: unilateral chest wall hematoma after intracranial aneurysm embolization

Unilateral chest wall hematoma is a rare but life-threatening cause of shock following endovascular procedures. We report a case of refractory hypotension and unilateral chest wall swelling in the post-anesthesia care unit, which was initially suspected to be a tension pneumothor...

Hemodynamic integration in extracorporeal membrane oxygenation anticoagulation

Despite progressive advances in circuit design, material biocompatibility, and anticoagulation monitoring, bleeding and thrombosis remain common during extracorporeal membrane oxygenation and are closely associated with adverse outcomes. Current practice still relies mainly on he...

Preliminary experience of mechanical thrombectomy treatment in pediatric arterial ischemic stroke: a retrospective case series

To evaluate the feasibility and efficacy of mechanical thrombectomy in the treatment of pediatric acute ischemic stroke (AIS). The clinical data, radiographic results and management outcomes of children diagnosed with AIS and treated at our hospital between 2016 and 2021 were ret...

Cross-KingdommiR5054 Delivery via Polygonum cuspidatum -Derived Nanoparticles Enhances Burn Wound Healingby Regulating Microvascular Environment

Abstract Deep partial-thickness burns are characterized by a self-perpetuating cycle of oxidative stress and inflammation that severely impedes healing. Here, we identified Polygonum cuspidatum-derived nanoparticles (PDNs) as a multifaceted nanotherapeutic that breaks this pathog...

Chondrosarcoma of the mobile spine: impact of tumor status at referral and surgical strategy on oncological outcome

BACKGROUND: Chondrosarcoma (CHS) is a rare malignant bone tumor, mostly histologically low grade, demonstrating limited response to chemotherapy and conventional photon radiotherapy (RT). According to Enneking Staging System, tumor-free margin en bloc resection is the cornerstone...