Zhoushan Hospital

Knockdown of CHI3L1 Attenuates Venous Intimal Hyperplasia by Modulating Vascular Inflammation and Oxidative Stress via the JNK/ERK Pathway

Background: Venous intimal hyperplasia (VIH) is the key pathological basis for early failure of arteriovenous fistula (AVF) and for stenosis of hemodialysis access. Chitinase-3-like protein 1 (CHI3L1) is highly expressed during cardiovascular remodeling and inflammation, but its...

Efficacy of hemodynamic profiling-guided antihypertensive therapy in elderly patients with early morning hypertension: a randomized controlled multicenter clinical study

Abstract Objective To evaluate the efficacy of hemodynamic profiling (HDpro)-guided antihypertensive therapy in elderly patients with uncontrolled morning hypertension. Methods A multicenter randomized controlled trial was conducted in 9 hospitals in Zhejiang Province, enrolling...

Environmental heterogeneity shapes divergent assembly processes and network stability of plankton communities along a tropical island coast: Evidence from Hainan Island

Understanding how plankton communities respond to environmental heterogeneity is essential for assessing tropical island coastal ecosystems and supporting region-specific management. Based on data from 59 environmental monitoring stations, including 16 stations with plankton samp...

A Deep Learning Approach for Bottom Detection in Multibeam Water-Column Data via Full-Swath Spatial Context

Bottom detection and tracking from multibeam echosounder water-column data constitute a fundamental step to 3D seabed mapping. Traditional methods based on amplitude thresholding and phase detection rely heavily on heuristic assumptions and are prone to failure in the presence of...

Antibiotic-loaded PMMA bone cement promotes diabetic wound healing via induced membrane formation: a transcriptomic and mechanistic study

Abstract DFU is a prevalent complication among diabetic patients, significantly impairing their quality of life.PMMA-induced membrane therapy has gained increasing attention as a specialized healing tissue closely linked to bone regeneration. This study aims to explore the impact...

Ship Docking Motion Prediction and Collision-Risk Early Warning Using a Physics–SVR Model

Reliable collision-risk warning during low-speed ship docking requires accurate and efficient hydrodynamic prediction. This study develops a physics-SVR (support vector regression) framework combining a three-degree-of-freedom maneuvering model with three SVR models that learn re...

Cross-tissue transcriptome association study identifies breast cancer susceptibility genes

Breast cancer (BC) is a common malignant tumor of the female reproductive system, with increasing incidence and mortality rates globally, which severely threatens women’s health. Although genetic factors have been confirmed to contribute to BC development, the specific pathogenic...