Zhongshan People's Hospital

How medical students experience disease-related information processing when a family member has cancer: a qualitative study

Communication of disease-related information in cancer care involves not only patients but also family members. In the Chinese family context, family members are often involved in obtaining, communicating, and processing illness-related information. However, little is known about...

ALKBH5-Dependent m 6 A Demethylation Promotes Cardiac Aging Through SLC38A3 Reduction and Glutamine Metabolic Alteration

BACKGROUND: N 6 -methyladenosine (m 6 A) modification has been linked to various types of physiological and pathological bioprocesses. However, the exact role of m 6 A mRNA methylation in cardiac aging is largely unknown. Here, we show that ALKBH5 (alpha-ketoglutarate-dependent d...

Genetic prioritization and multi-omic characterization of GNS-associated thromboinflammatory signatures in venous thromboembolism

Venous thromboembolism (VTE) remains a major cause of cardiovascular morbidity and mortality. Beyond dysregulated coagulation, accumulating evidence implicates immune and inflammatory pathways in thromboinflammatory susceptibility. However, the genetic determinants of VTE and the...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Crucial role of telomere maintenance-related genes in survival prediction and subtype identification in colorectal cancer

Abstract Telomere maintenance genes are closely related to colorectal cancer (CRC) development and progression. However, the potential influence of telomere maintenance-related genes (TMRGs) on the prognosis of CRC and their clinical relevance remains insufficiently explored. Uti...

From Clinical Technique to Interprofessional Implementation and Intelligent Integration: A Bibliometric Analysis of the Interdisciplinary Expansion of Robot‐Assisted Spine Surgery

BACKGROUND: Robot-assisted spine surgery (RASS) has expanded beyond technical accuracy towards interprofessional, perioperative, and AI-driven implementation, yet this interdisciplinary evolution has not been systematically characterised. METHODS: We analysed 327 Web of Science C...

Procalcitonin for diagnosing infected pancreatic necrosis: a systematic review and meta-analysis

Abstract Background Infected pancreatic necrosis (IPN) ranks among the most severe local complications of acute pancreatitis (AP) and plays a central role in driving AP-related death. Procalcitonin (PCT), a serum biomarker that responds preferentially to bacterial infection, has...

Allergic Inflammation and the IL-33/ST2 Axis in Childhood Asthma: A Narrative Review of Related Pathways and Intervention Strategies

Background: Pediatric asthma is the most common disease in children, and its incidence is increasing globally. Its clinical features are usually wheezing, dyspnea, cough, and increased airway sensitivity. Exposure to dust mites in the living environment, air pollutants, and virus...