Zhongda Hospital Southeast University

Multimodal Transformer Integrating CT and Pathology for Postoperative Risk Stratification in Stage I Non–Small Cell Lung Cancer

A biologically interpretable multimodal artificial intelligence framework outperformed guideline-based postoperative risk stratification for stage I non–small cell lung cancer and identified patients who would benefit from adjuvant therapy.

Substrate stiffness regulates cell fate and its applications in the repair of motor system: From two dimensions to three dimensions

Abstract Stiffness is a key mechanical cue of the extracellular matrix (ECM) and biomaterials in tissue engineering. It plays a pivotal role in regulating cellular behaviors and determining cell fate through specific mechanotransduction pathways, including integrin‐mediated signa...

Hepatobiliary phase imaging in HCC: revisiting diagnostic algorithms and clinical utility of gadoxetic acid-enhanced MRI across international guidelines

Abstract Hepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality worldwide. In at-risk populations, noninvasive imaging diagnosis relies primarily on the vascular hallmarks of arterial phase hyperenhancement and washout appearance. However, these features...

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

ABSTRACT Intervertebral disc degeneration (IVDD) is a major cause of low back pain and is closely associated with metabolic imbalance within the disc microenvironment, yet the underlying mechanisms remain poorly understood. Here, we identify ammonia accumulation as a metabolicall...

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

ABSTRACT Microwave ablation (MWA) for large hepatocellular carcinoma (HCC) is frequently compromised by non‐uniform thermal distribution and immunosuppressive niche formation. To address these challenges, we engineered an injectable bimodal nanodepot (TCPD) via catalytic crosslin...

Functional myocardial ischemia assessment based on HF-ECG microstructural features

Early detection and stratification of functional myocardial ischemia are critical for timely intervention but remain constrained by the limited sensitivity of conventional electrocardiography (ECG) and the cost and accessibility of imaging-based diagnostics. We present a non-inva...

PediatricLiver score: a novel risk score for screening elevated liver stiffness in the pediatric population (CHESS2401)

Given the looming crisis of rapid increase in childhood obesity globally, chronic metabolic diseases have consequently emerged but without sufficient awareness among children. Reliable and accessible screening tools thus are required to screen for significant liver fibrosis in th...

Hospice care volunteers’ experiences of reflecting on life meaning: a descriptive phenomenological study

Hospice care volunteers are an important part of spiritual care in hospice settings. Through active listening and dialogue, they can help terminally ill patients rediscover and affirm the value of life and the meaning of existence that may have been obscured during illness. Howev...

From endovascular therapy to perivascular therapy: A new concept and perspective

The cardiovascular system relies on an organ-spanning vascular network not only for transport but also for systemic homeostatic control. Surrounding the vessel wall is a complex perivascular microenvironment, including the vasa vasorum, autonomic and sensory nerves, perivascular...

Potential therapeutic effects of Lactobacillus on Pancreatic ductal adenocarcinoma through its metabolite Harmaline

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal form of cancer. Recent research has uncovered the role of the gut microbiota in influencing PDAC progression and treatment outcomes. Dysbiosis of gut microbiota in PDAC patients has been shown to negatively...

Monocyte-to-HDL cholesterol ratio and cardiovascular comorbidity in COPD

Chronic obstructive pulmonary disease (COPD) is frequently complicated by cardiovascular disease (CVD), which significantly increases morbidity and mortality. The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) has emerged as a novel inflammatory biomarker associated...

An expert-level generalist AI for abdominal CT diagnosis

Artificial intelligence (AI) in radiology aspires to deliver expert-level diagnosis across diverse clinical tasks, yet existing supervised strategies remain limited in scope. We developed RADAR, a generalist vision-language model trained on more than 400,000 contrast-enhanced abd...

Association between sarcopenia and hypertension: results from large databases in China and the United States

Sarcopenia and hypertension are prevalent conditions with substantial public health implications. However, whether their association is consistent across different populations remains unclear. This study aimed to investigate the association between sarcopenia and hypertension usi...

Deep learning CT signature for predicting early liver metastases in pancreatic ductal adenocarcinoma

Accurately predicting the risk of early liver metastases (ELM) and identifying patients who are most likely to benefit from neoadjuvant therapy (NAT) are critical for pancreatic ductal adenocarcinoma (PDAC). Here, we develop a Mamba-based predictive model that integrates imaging...

Combined stress hyperglycemia ratio and glycemic variability phenotypes with severe acute kidney injury after cardiac surgery across glucose metabolic states

Stress hyperglycemia ratio (SHR) and glycemic variability (GV) capture different aspects of acute glycemic disturbance, but their joint association with severe acute kidney injury (AKI) after cardiac surgery remains unclear. This retrospective MIMIC-IV cohort included adults unde...

Conservative versus liberal oxygen therapy for mechanically ventilated adults: a systematic review with meta-analysis and trial sequential analysis

Optimal oxygen targets for mechanically ventilated adults remain uncertain. Prior meta-analyses included both ventilated and non-ventilated patients, limiting applicability to invasive ventilation. We performed a PRISMA-compliant systematic review and meta-analysis of randomized...

Effect of early parenteral nutrition versus enteral nutrition alone on all‐cause mortality in critically ill adults: A systematic review and meta‐analysis

Abstract Background For nutritional support in critically ill patients, the early initiation of enteral nutrition (EN) in the presence of gastrointestinal function has been agreed upon by most scholars. However, EN support alone cannot fully meet the needs of the body in some cas...

Polygenic risk score analysis for major depressive disorder in a Chinese cohort: single-phenotype and pathway-based approaches

Abstract Background Major depressive disorder (MDD) is a global mental health challenge characterized by high prevalence, disability, and recurrence, with its susceptibility showing substantial polygenic inheritance. Polygenic risk scores (PRS) provide a novel method to explore c...

Hepatocyte Hedgehog activation attenuates acetaminophen-induced liver injury through a Vegfa-associated vascular response

Abstract Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure, yet early pathways linking hepatocellular stress to tissue integrity remain incompletely defined. Here, we demonstrate that canonical Hh signaling is rapidly activated in centrilobula...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...