Zhengzhou Jinshui District General Hospital

Serial versus updated MELD for conditional 28-day mortality in critically ill patients with cirrhosis and sepsis: a landmark cohort study

Whether an admission-window Model for End-stage Liver Disease (MELD) score adds predictive information once an updated score is known remains uncertain in critically ill patients with cirrhosis and sepsis. We studied adults in MIMIC-IV v3.1 who were alive and hospitalized 72 h af...

Probiotic Spore Inspired Oral Drug Delivery System With Multiple‐Barriers‐Crossing Ability Modulates Gut‐Brain Axis for Parkinson's Disease Therapy

ABSTRACT For Parkinson's disease (PD), the development of oral brain‐targeted drug delivery is challenging due to various physiological barriers. Besides the brain, the effect of the gut on the microbiome‐gut‐brain axis should not be ignored. Therefore, developing a gut‐brain dua...