Zhengzhou Central Hospital

Association of long-term depressive burden with incident cardiometabolic multimorbidity: a prospective study in middle-aged and older adults across three continents

Background: Cardiometabolic multimorbidity (CMM) is a growing concern as global population ages. Although baseline depression is a recognised risk factor for chronic diseases, the dynamic and cumulative effect of depression on CMM remains unclear. We aimed to evaluate the longitu...

M1 macrophage‐derived exosomes aggravate diabetic nephropathy by regulating the WTAP / S1PR2 axis

BACKGROUND: Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus. The specific role of M1 macrophage-derived exosomes in DN progression remains largely unexplored. METHODS: THP-1 monocytes were differentiated into M0 macrophages and polarized into...

A boundary-guided strategy via pseudo-anomaly feature perception for unsupervised ECG signal quality assessment

Electrocardiogram (ECG) signal quality assessment is vital for ensuring accurate ECG diagnoses and efficient medical services. Traditional supervised ECG signal quality assessment methods are limited by a restricted set of noise categories, which results in poor generalization ab...

Antioxidant nanozymes for regenerative medicine: mechanisms, design, and applications in tissue repair

Natural antioxidant enzymes play a central role in regulating oxidative stress within living organisms. During tissue repair following injury, these enzymes act synergistically to scavenge excess reactive oxygen species and maintain cellular redox homeostasis, thereby supporting...

U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure

Importance Left ventricular structural assessment is fundamental in heart failure (HF). However, the independent prognostic value of left ventricular size beyond its association with ejection fraction remains poorly defined in real-world, large-scale populations. Objective To inv...

The highly expressed lncRNA TRG-AS1 in serum specifically inhibits miR-139-5p, thereby promoting oxidative stress and inflammation in heart failure

Patients with chronic heart failure (CHF) have a high mortality rate. The aim of this research is to examine the clinical value and molecular mechanisms of the lncRNA T cell receptor gamma chain-associated AS1 (TRG-AS1) in CHF. The TRG-AS1 expression in 116 CHF patients was asses...

Neutrophil percentage-to-albumin ratio is associated with in-hospital mortality in patients with acute aortic dissection: a multicenter retrospective cohort study

Early risk stratification remains challenging in patients with acute aortic dissection (AAD). This study aims to evaluate the prognostic value of neutrophil percentage-to-albumin ratio (NPAR) for in-hospital mortality in patients with acute aortic dissection. We performed a multi...