Zhejiang Taizhou Hospital

Next-generation natural killer cell therapy: bench to bedside and beyond

Natural killer (NK) cells have emerged as central players in cancer immunotherapy, progressing from basic discovery to clinically validated platforms over five decades. This review synthesizes the evolving understanding of NK cell biology, including subset heterogeneity, epigenet...

Associations between patient safety culture, occupational exposure behaviours and patient safety behaviours among operating theatre nurses: a multicentre cross-sectional study

Patient safety in operating theatres is influenced by organisational safety culture and nurses’ safety-related behaviours. Occupational exposure remains a frequent hazard in perioperative settings; however, its relationship with patient safety culture (PSC) and patient safety beh...

Laparoscopic one-stage operation for completely perforated choledochal cyst: two cases report and review of the literature

Choledochal cyst (CDC) perforation is a rare but serious complication, and the optimal surgical strategy remains controversial. To our knowledge, no case of laparoscopic one-stage surgery for a completely perforated CDC with a perforation time exceeding 24 h has been reported. We...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

MRC1⁺ macrophages and endothelial PTPRM signalling characterize a microvascular invasion–associated tumor ecosystem in hepatocellular carcinoma

The intercellular interactions and molecular features underlying microvascular invasion (MVI) in hepatocellular carcinoma (HCC) remain incompletely understood. We aimed to characterize the MVI-associated multicellular ecosystem at single-cell resolution and to derive prognostic a...

Determination of Hecogenin in Mouse Blood by UPLC–MS/MS and Applied to a Pharmacokinetic Study

ABSTRACT Hecogenin, a steroidal sapogenin from agave plants, exhibits anti‐inflammatory, anti‐tumor, gastroprotective, and diuretic activities. A sensitive ultraperformance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) method was developed and validated for quantify...

Study of tumor control probability by stereotactic body radiotherapy with first-generation EGFR-TKIs

Our previous study suggested that patients with advanced epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma treated with first-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs) followed by standard-dose stereotactic body radiotherapy (SBRT) had a larger area...

Serum ferritin and ADHD in children: a case-control study accounting for inflammation

To evaluate the association between serum ferritin (SF) and attention-deficit/hyperactivity disorder (ADHD) in children while accounting for C-reactive protein (CRP). This retrospective case-control study included 156 children with DSM-5 ADHD and 164 healthy controls aged 6–12 ye...

Preoperative lung ultrasound score and multifactorial predictors of 1-year mortality in geriatric hip fracture patients with pneumonia: a retrospective cohort study

Abstract Background Preoperative pneumonia severity independently predicts postoperative mortality in elderly hip fracture patients, yet accurate assessment remains challenging. This study evaluated lung ultrasound score (LUS) for predicting 1-year mortality and compared its pred...

Prophylactic Low-Dose Dexamethasone for Postoperative Pulmonary Complications in Type B Aortic Dissection: A Retrospective Cohort Study

AIM: To evaluate the impact of prophylactic low-dose glucocorticoids on the incidence of postoperative pulmonary complications (PPCs) and perioperative recovery parameters in patients undergoing surgery for type B aortic dissection.METHODS: This retrospective cohort study analyze...

Chemotherapy remains effective in ALK-TKI therapy: a retrospective analysis in ALK-positive advanced NSCLC

Tyrosine kinase inhibitors (TKIs) are the standard therapy for advanced non-small cell lung cancer (NSCLC) harboring anaplastic lymphoma kinase (ALK) fusions. However, acquired resistance remains a major challenge, necessitating strategies to prolong therapeutic efficacy. This st...

Differentiating Chlamydia psittaci pneumonia from community-acquired pneumonia using clinical features and computed tomography findings

Chlamydia psittaci pneumonia (CPP) is a rare disease that is difficult to diagnose. Its clinical manifestations and chest imaging findings often overlap with those of other types of community-acquired pneumonia (CAP), and nonspecific treatment is likely to lead to rapid disease p...